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Filtering by: Creator Bitar, Rafiha C. Remove constraint Creator: Bitar, Rafiha C. Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • A role for ceramide accumulation in age-related cardiac mitochondrial dysfunction

    Creator:
    Monette, Jeffrey S.
    Abstract:
    Ceramides are a group of lipids in the sphingolipid family that are potent cell signaling molecules. Elevations in ceramide levels above the norm generally lead to apoptosis. Evidence from in vitro studies suggests that accumulation of ceramides within mitochondria leads to dysfunction of the mitochondria. This includes inhibition of the...
    Resource Type:
    Dissertation
    Full Text:
    the cell as they promote membrane permeability transition, which allows the release of cytochrome c