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Filtering by: Creator Brown, Adam C. Academic Affiliation Biochemistry and Biophysics

Rapamycin and Dietary Restriction Induce MetabolicallyDistinctive Changes in Mouse Liver

Creator:

Yu, Zhen, Wang, Rong, Fok, Wilson C., Coles, Alexander, Salmon, Adam B., and Pérez, Viviana I.

Abstract:

Dietary restriction (DR) is the gold standard intervention used to delay aging, and much recent research has focused on the identification of possible DR mimetics. Energy sensing pathways, including insulin/IGF1 signaling, sirtuins, and mammalian Target of Rapamycin (mTOR), have been proposed as pathways involved in the antiaging actions of DR,...

Resource Type:

Article
Short-Term Treatment With Rapamycin and Dietary Restriction Have Overlapping and Distinctive Effects in Young Mice

Creator:

Fok, Wilson C., Zhang, Yiqiang, Salmon, Adam B., Bhattacharya, Arunabh, Gunda, Rakesh, Jones, Dean, Ward, Walter, Fisher, Kathleen, Richardson, Arlan, and Perez, Viviana I.

Abstract:

Because rapamycin, an inhibitor of the nutrient sensor mammalian target of rapamycin, and dietary restriction both increase life span of mice, it has been hypothesized that they act through similar mechanisms. To test this hypothesis, we compared various biological parameters in dietary restriction mice (40% food restriction) and mice fed...

Resource Type:

Article

Full Text:

rst discovered in the soil of Easter Island. Brown and coworkers ( 3 ) found that rapamycin