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Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Creator:: Davis, Ralph Eugene, 1957-
Abstract:: Vaccinia virus infected monkey kidney cells had been previously shown to have an increased ribonucleoside diphosphate reductase (RR) activity. DNA from mutant virus resistant to hydroxyurea were digested with restriction endonucleases and were shown to have substoichiometric amounts of the Hind III F fragment. Additional information from Southern blotting experiments...
Resource Type:: Dissertation
Full Text:: THESIS OF Ralph Eugene Davis for the degree of _Qoctor of Philosophy in Biochemistry and Biophysics

Large subunit of vaccinia cirus ribonucleotide reductase : affinity chromatography-based purification and photoaffinity labeling

Creator:: Warth, Rainer K.
Abstract:: Ribonucleoside diphosphate reductase (RR) from vaccinia virus was recently cloned and overexpressed rn Escherichia coli. The amino acid sequence identities of the small and large subunits between the mouse and the vaccinia virus reductase are approximately 80 and 72 percent, respectively. In addition, vaccinia virus RR displays similar complex allosteric...
Resource Type:: Masters Thesis
Full Text:: Purification and Photoaffinity Labeling Abstract approved: Christopher K. Mathews, Ph.D. Ribonucleoside

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Creator:: Purohit, Sarla
Abstract:: The dihydrofolate reductase gene of bacteriophate T4 has been investigated at the structural level to elucide the unusual regulation of expression of this gene and possible evolutionary relationships between the ohage and drug resistance factors-encoded dihydrofolate reductases (DHFR). A 1.1-kilobase-pair restriction fragment of the T4 multiple mutant dec8 containing frd,...
Resource Type:: Dissertation
Full Text:: I thank Dr. Christopher K. Mathews for his guidance and support. His patience, stimulating

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Creator:: Howell, Meredith L.
Abstract:: Ribonucleotide reductase is a remarkable enzyme that catalyzes the rate-limiting step in the synthesis of the 2'-deoxynucleoside triphosphates. The intent of this project was to characterize the ribonucleotide reductase encoded by the orthopoxvirus, vaccinia. The first objective was to study the structural and functional features of the viral small subunit...
Resource Type:: Dissertation
Full Text:: and Characterization of the Recombinant Small Subunit Protein Abstract approved: C. K. Mathews

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Creator:: Ungermann, Christian
Resource Type:: Masters Thesis
Full Text:: the Bacteriophaoe T4-coded dCTPase- dUTPase Abstract approved: C ristopher K. Mathews, Ph.D. The

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Creator:: Hendricks, Stephen P.
Abstract:: The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...
Resource Type:: Dissertation
Full Text:: Activities. Abstract approved: Christopher K. Mathews The first committed step in DNA biosynthesis

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Creator:: Hanson, Eric Scott
Resource Type:: Dissertation
Full Text:: members of the Mathews' group, both past and present. I especially wish to thank Ralph Davis, Patrick

Prostaglandin F α-induced signal transduction mechanism regulating the secretion of oxytocin from the bovine corpus lutem

Creator:: Orwig, Kyle Edwin
Resource Type:: Dissertation

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Creator:: Sargent, Roy Geoffrey
Abstract:: Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic for DNA synthesis in both intact cells and cell-free replication systems. Almost certainly, such mutagenesis involves competition between correctly and incorrectly base-paired precursors at replication sites. However, there are certain differences between the intact cell and cell-free systems that do not always allow...
Resource Type:: Dissertation
Full Text:: privacy Christopher K. Mathews Imbalanced deoxyribonucleoside triphosphate (dNTP) pools are mutagenic

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

Creator:: Ray, Nancy Bisset
Resource Type:: Dissertation
Full Text:: . Mathews, for the advice and support he has provided throughout my graduate studies. I would also like to

ScholarsArchive@OSU

Vaccinia virus ribonucleotide reductase : gene sequencing, intracellular localization, and interaction with a DNA-binding protein

Large subunit of vaccinia cirus ribonucleotide reductase : affinity chromatography-based purification and photoaffinity labeling

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Vaccinia virus ribonucleotide reductase : regulation of the gene products and characterization of the recombinant small subunit protein

Protein-protein interactions in the bacteriophage T4-coded dCTPase-dUTPase

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Prostaglandin F α-induced signal transduction mechanism regulating the secretion of oxytocin from the bovine corpus lutem

Deoxyribonucleotides as determinants of DNA replication fidelity in bacteriophage T4

Nucleoside diphosphokinase of Escherichia coli and its interactions with bacteriophage T4 proteins of DNA synthesis

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