Index Catalog // ScholarsArchive@OSU

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

Creator:: Shen, Rongkun
Abstract:: The enzymes of dNTP synthesis in T4 infection associate to form a multienzyme complex, the T4 dNTP synthetase complex, facilitating the flow of metabolites en route to dNTPs, and their subsequent flow into DNA. Study of protein-protein interactions helps one to understand how the enzymes in the complex are organized...
Resource Type:: Dissertation

The effect of hexachlorophene and related compounds on torula yeast glucose-6-phosphate dehydrogenase and some other dehydrogenase enzymes

Creator:: Wang, Jun-Lan
Abstract:: Low concentrations of hexachlorophene (HCP) inhibit a number of pyridine nucleotide-linked dehydrogenase enzymes. The I₅₀ HCP concentrations were 105 μM for pig heart isocitrate dehydrogenase (ICD), 65 μM for horse liver alcohol dehydrogenase, 39 μM for torula yeast glucose-6-phosphate dehydrogenase (G6PD), 6.0 μM for beef heart malate dehydrogenase, and 1.6...
Resource Type:: Dissertation
Full Text:: Dehydrogenase Glucose-6-phosphate dehydrogenase (G6PD; D-glucose-6-phosphate: NADP + -oxidoreductase, EC

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Creator:: Purohit, Sarla
Abstract:: The dihydrofolate reductase gene of bacteriophate T4 has been investigated at the structural level to elucide the unusual regulation of expression of this gene and possible evolutionary relationships between the ohage and drug resistance factors-encoded dihydrofolate reductases (DHFR). A 1.1-kilobase-pair restriction fragment of the T4 multiple mutant dec8 containing frd,...
Resource Type:: Dissertation
Full Text:: deoxycytidylate hydroxymethylase (HMase; EC. 2.1.2.b) be- longs to this second category and functions in the

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation

Adenovirus complementary strand synthesis in vivo

Creator:: Wang, Kai, 1955-
Abstract:: Replication of plasmid molecules containing a single adenovirus terminal sequence and specially arranged inverted repeat sequences were studied. When the plasmids were linearized to expose the adenovirus terminal sequence and transfected into 293 cells with helper adenovirus DNA, a larger molecule was detected. The new molecule contained adenovirus terminal sequences...
Resource Type:: Dissertation
Full Text:: size analysis of the adenovirus replicon. EMBO 3, 333-337. 76. Hay, R. T., Stow, N. D. and McDougall

Protein methylation at sites of blood vessel injury

Creator:: Weber, Darin J.
Abstract:: Blood vessel injury was found to release intracellular pools of protein D-aspartyl/L-isoaspartyl carboxyl methyltransferase (PIMT) into the extracellular milieu, where it became trapped. Trapped PIMT was able to utilize radiolabeled S-adenosyl-L-methionine (AdoMet) introduced into the circulation to methylate blood vessel proteins containing altered aspartyl residues specifically at the site of...
Resource Type:: Dissertation
Full Text:: methyltransferase (EC 2.1.1.77) purified from rabbit erythrocytes (Gilbert et al. 1988) was added to the assay

Nucleoprotein structure of adenovirus

Creator:: Corden, Jeffry Lynn
Abstract:: The structure of the nucleoprotein core of adenovirus has been investigated. Using a combination of biophysical techniques and nuclease digestion I have determined that the adenovirus core, as isolated with pyridine, shares several physical properties with cellular chromatin. The most notable difference is the lack of a nucleosome repeat in...
Resource Type:: Dissertation
Full Text:: nuclei with staphylococcal nuclease (nucleate 3'-oligonucleotido hydrolase, EC 3.1.4.7, referred to as

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Creator:: Nian, Hui
Abstract:: Histone deacetylase (HDAC) inhibitors have the potential to de-repress epigenetically silenced genes in cancer cells, leading to cell cycle arrest and apoptosis. Dietary HDAC inhibitors derived from natural phytochemicals are promising anticancer agents. In this thesis, metabolites from natural organosulfur and organoselenium compounds, i.e. allyl mercaptan (AM), β-methylselenopyruvate (MSP) and...
Resource Type:: Dissertation

Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism

Creator:: Schmidt, Edward Eric
Resource Type:: Dissertation

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation

ScholarsArchive@OSU

Protein-protein interactions in the bacteriophage T4 dNTP synthetase complex

The effect of hexachlorophene and related compounds on torula yeast glucose-6-phosphate dehydrogenase and some other dehydrogenase enzymes

Bacteriophage T4-coded dihydrofolate reductase : cloning and structural analysis of its gene and organization of flanking regions

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Adenovirus complementary strand synthesis in vivo

Protein methylation at sites of blood vessel injury

Nucleoprotein structure of adenovirus

Dietary organosulfur and organoselenium compounds as HDAC inhibitors

Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

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