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Filtering by: Alternative title ssim EM 9033 Academic Affiliation Biochemistry and Biophysics

Age-related decrease in resilience against acute redox cycling agents: Critical role of declining GSH-dependent detoxification capacity

Creator:

Thomas, Nicholas O.

Abstract:

Over the past century, life expectancy in the United States has dramatically increased leading to an increasingly aging population with people reaching, and spending more years in ‘old age’. While this unprecedented shift in population demographics represents great strides for humanity, it is not without cost. One consequence of longer...

Resource Type:

Dissertation
Characterization of neuronal nitric-oxide synthase reductase activity

Creator:

Wolthers, Kirsten R.

Abstract:

During catalysis the flavoprotein domain of neuronal nitric-oxide synthase (nNOS) shuttles NADPH-derived reducing equivalents from FAD to FMN and then to the P450-heme enabling heme-based oxygen activation and subsequent NO-synthesis. The binding of Ca²⁺-activated calmodulin (Ca²⁺-CaM) to nNOS alleviates inhibition of flavin mediated electron transfer within the diflavin domain, which...

Resource Type:

Dissertation