Index Catalog // ScholarsArchive@OSU

Deletion of gene clusters to identify novel secondary metabolites in Fusarium graminearum

Creator:: Husk, Jacob, Connolly, Lanelle, and Freitag, Michael
Abstract:: CGRB Fall Conference 2015
Resource Type:: Poster
Full Text:: Michael Freitag PmeISwaI SecMet cluster DNA Scheme 3: Capture whole clusters with plasmid marker+ 5

Building a bridge from chromosomes to microtubules in Neurospora crassa

Creator:: Friedman, Steven
Abstract:: DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
Resource Type:: Dissertation
Full Text:: (L. Connolly, S. Shahi, M. Rep, L. Fokkens, S.-H. Yun and M. Freitag, in preparation) than what is

Proteins in Motion: Protein Dynamics of Cataracts, and Interactions Between the COVID-19 Virus and its RNA Genome

Creator:: Masson-Forsythe, Heather M.
Abstract:: Just as the structure of a protein determines its function, protein motions and lack-of-structure are also key to regulating protein behavior. The human eye lens is made up of high concentrations of extremely stable crystallin proteins, but even in this context, small motions over time can cause a loss of...
Resource Type:: Dissertation

The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

Creator:: Connolly, Lanelle R., Smith, Kristina M., and Freitag, Michael
Abstract:: The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for trimethylated histone H3 lysine 27 (H3K27me3), a...
Resource Type:: Article

Antimicrobial peptide regulation by small molecules in humans and other primates

Creator:: Sinnott, Brian D.
Abstract:: Antimicrobial peptides (AMPs) play an important role in the innate immune system. Determining the pathways by which these proteins are regulated allows for modulation of their expression for better health. Two families of antimicrobial peptides have been studied in humans: cathelicidins and defensins. There is a single cathelicidin in humans...
Resource Type:: Masters Thesis
Full Text:: .............................................................................. 17 5. Q-PCR for CAMP with increasing doses of 1,25(OH)2 D3 with 10-5 M disulfarim in U937 cells

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: committee for their valuable guidance: Drs. David Hen- drix, John Henning, Michael Freitag, Maria Clara

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Creator:: Wang, Yizhou, Smith, Kristina M., Taylor, John W., Freitag, Michael, and Stajich, Jason E.
Abstract:: Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used...
Resource Type:: Article
Full Text:: ., Smith, K. M., Taylor, J. W., Freitag, M., & Stajich, J. E. (2015). Endogenous small RNA mediates

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Creator:: Ding, Jun
Abstract:: The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
Resource Type:: Dissertation
Full Text:: Freitag, and Dr. Fred Stevens for their advice and help towards the completion of my program. Many

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Creator:: Hall, Justin Daniel
Abstract:: Cytoplasmic dynein is an ATP-dependent, microtubule-based molecular motor involved in the positioning and trafficking of cellular cargo. The cargo binding sub-domain of dynein contains the natively disordered intermediate chain (IC) and the homodimeric light chains (Tctex1, LC8 and LC7). The structure and stoichiometry of this complex, how the light chains...
Resource Type:: Dissertation
Full Text:: , Michael Freitag and Christopher Mathews, I would like to thank Rick Faber and Dale Tronrud for distinct

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

Creator:: Guo, Chunxiao
Abstract:: Human cathelicidin antimicrobial peptide (CAMP/LL-37) is a cationic antimicrobial peptide that is widely expressed by myeloid and epithelial cells at the human-environment interface. It possesses broad spectrum antimicrobial capacity against bacteria, fungi and viruses. In addition to its direct antimicrobial activity, CAMP/LL-37 also attracts and recruits monocytes, neutrophils and other...
Resource Type:: Dissertation
Full Text:: his laboratory and the freedom to pursue insane ideas. I thank Michael Freitag for his help and

ScholarsArchive@OSU

Deletion of gene clusters to identify novel secondary metabolites in Fusarium graminearum

Building a bridge from chromosomes to microtubules in Neurospora crassa

Proteins in Motion: Protein Dynamics of Cataracts, and Interactions Between the COVID-19 Virus and its RNA Genome

The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

Antimicrobial peptide regulation by small molecules in humans and other primates

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Biophysical basis of macromolecular assembly in the dynein cargo attachment complex

Transcriptional regulation of the human cathelicidin antimicrobial peptide gene

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