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Filtering by: Committee Member Hagen, Tory Academic Affiliation Biochemistry and Biophysics

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:

Beilby, Pamela R.

Abstract:

Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...

Resource Type:

Dissertation

Full Text:

, Kathy Magnusson, Barb Taylor, and Tory Hagen, who have provided guidance and encouragement
Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

Creator:

Martomo, Stella A.

Abstract:

Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...

Resource Type:

Dissertation

Full Text:

, Dr. Tory Hagen and Dr. Soichi Kimura; also Dr. Isaac Wong. Dr. Jeff Greenwood, Dr. Sam Bradford
Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:

Stoner, Christopher S.

Abstract:

Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...

Resource Type:

Dissertation