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The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

Creator:: Connolly, Lanelle R., Smith, Kristina M., and Freitag, Michael
Abstract:: The cereal pathogen Fusarium graminearum produces secondary metabolites toxic to humans and animals, yet coordinated transcriptional regulation of gene clusters remains largely a mystery. By chromatin immunoprecipitation and high-throughput DNA sequencing (ChIP-seq) we found that regions with secondary metabolite clusters are enriched for trimethylated histone H3 lysine 27 (H3K27me3), a...
Resource Type:: Article

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Creator:: Wang, Yizhou, Smith, Kristina M., Taylor, John W., Freitag, Michael, and Stajich, Jason E.
Abstract:: Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used...
Resource Type:: Article
Full Text:: Transposon Yizhou Wang,*,† Kristina M. Smith,‡ John W. Taylor,§ Michael Freitag,‡ and Jason E. Stajich*,1

Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence

Creator:: Lepesant, Julie M. J., Cosseau, Celine, Boissier, Jerome, Freitag, Michael, Portela, Julien, Climent, Deborah, Perrin, Cecile, Zerlotini, Adhemar, and Grunau, Christoph
Abstract:: Background: In the leuphotrochozoan parasitic platyhelminth Schistosoma mansoni, male individuals are homogametic (ZZ) whereas females are heterogametic (ZW). To elucidate the mechanisms that led to the emergence of sex chromosomes, we compared the genomic sequence and the chromatin structure of male and female individuals. As for many eukaryotes, the lower...
Resource Type:: Article
Full Text:: emergence Julie MJ Lepesant1*, Céline Cosseau1, Jérome Boissier1, Michael Freitag2, Julien Portela1, Déborah

Heterokaryon Incompatibility Is Suppressed Following Conidial Anastomosis Tube Fusion in a Fungal Plant Pathogen

Creator:: Ishikawa, Francine H., Souza, Elaine A., Shoji, Jun-ya, Connolly, Lanelle, Freitag, Michael, Read, Nick D., and Roca, M. Gabriela
Abstract:: It has been hypothesized that horizontal gene/chromosome transfer and parasexual recombination following hyphal fusion between different strains may contribute to the emergence of wide genetic variability in plant pathogenic and other fungi. However, the significance of vegetative (heterokaryon) incompatibility responses, which commonly result in cell death, in preventing these processes...
Resource Type:: Article
Full Text:: . Souza1*, Jun-ya Shoji3, Lanelle Connolly2, Michael Freitag2, Nick D. Read3, M. Gabriela Roca3 1

Genes Related to Ion-Transport and Energy Production Are Upregulated in Response to CO₂-Driven pH Decrease in Corals: New Insights from Transcriptome Analysis

Creator:: Vidal-Dupiol, Jeremie, Zoccola, Didier, Tambutté, Eric, Grunau, Christoph, Cosseau, Céline, Smith, Kristina M., Freitag, Michael, Dheilly, Nolwenn M., Allemand, Denis, and Tambutté, Sylvie
Abstract:: Since the preindustrial era, the average surface ocean pH has declined by 0.1 pH units and is predicted to decline by an additional 0.3 units by the year 2100. Although subtle, this decreasing pH has profound effects on the seawater saturation state of carbonate minerals and is thus predicted to...
Resource Type:: Article
Full Text:: , Kristina M. Smith4, Michael Freitag4, Nolwenn M. Dheilly2,3, Denis Allemand1, Sylvie Tambutté1 1 Centre

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

Creator:: Roquis, David, Lepesant, Julie M. J., Picard, Marion A. L., Freitag, Michael, Parrinello, Hugues, Groth, Marco, Emans, Rémi, Cosseau, Céline, and Grunau, Christoph
Abstract:: Background: Chromatin structure can control gene expression and can define specific transcription states. For example, bivalent methylation of histone H3K4 and H3K27 is linked to poised transcription in vertebrate embryonic stem cells (ESC). It allows them to rapidly engage specific developmental pathways. We reasoned that non-vertebrate metazoans that encounter a...
Resource Type:: Article
Full Text:: David Roquis1,2☯, Julie M. J. Lepesant1,2☯, Marion A. L. Picard1,2☯, Michael Freitag3, Hugues

The putative protein methyltransferase LAE1 controls cellulase gene expression in Trichoderma reesei

Creator:: Seiboth, Bernhard, Karimi, Razieh Aghcheh, Phatale, Pallavi A., Linke, Rita, Hartl, Lukas, Sauer, Dominik G., Smith, Kristina M., Baker, Scott E., Freitag, Michael, and Kubicek, Christian P.
Abstract:: Trichoderma reesei is an industrial producer of enzymes that degrade lignocellulosic polysaccharides to soluble monomers, which can be fermented to biofuels. Here we show that the expression of genes for lignocellulose degradation are controlled by the orthologous T. reesei protein methyltransferase LAE1. In a lae1 deletion mutant we observed a...
Resource Type:: Article
Full Text:: Karimi,1† Pallavi A. Phatale,2 Rita Linke,1,3 Lukas Hartl,1 Dominik G. Sauer,1 Kristina M. Smith,2

Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator

Creator:: Karimi-Aghcheh, Razieh, Bok, Jin Woo, Phatale, Pallavi A., Smith, Kristina M., Baker, Scott E., Lichius, Alexander, Omann, Markus, Zeilinger, Susanne, Seiboth, Bernhard, Rhee, Catherine, Keller, Nancy P., Freitag, Michael, and Kubicek, Christian P.
Abstract:: The putative methyltransferase LaeA is a global regulator that affects the expression of multiple secondary metabolite gene clusters in several fungi, and it can modify heterochromatin structure in Aspergillus nidulans. We have recently shown that the LaeA ortholog of Trichoderma reesei (LAE1), a fungus that is an industrial producer of...
Resource Type:: Article
Full Text:: Woo Bok,† Pallavi A. Phatale,‡ Kristina M. Smith,‡ Scott E. Baker,§ Alexander Lichius,* Markus Omann

Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites

Creator:: Wiemann, Philipp, Sieber, Christian M. K., von Bargen, Katharina W., Studt, Lena, Niehaus, Eva- Maria, Espino, Jose J., Huß, Kathleen, Michielse, Caroline B., Albermann, Sabine, Wagner, Dominik, Bergner, Sonja V., Connolly, Lanelle R., Fischer, Andreas, Reuter, Gunter, Kleigrewe, Karin, Bald, Till, Wingfield, Brenda D., Ophir, Ron, Freeman, Stanley, Hippler, Michael, Smith, Kristina M., Brown, Daren W., Proctor, Robert H., Munsterkotter, Martin, Freitag, Michael, Humpf, Hans-Ulrich, Guldener, Ulrich, and Tudzynski, Bettina
Abstract:: The fungus Fusarium fujikuroi causes "bakanae" disease of rice due to its ability to produce gibberellins (GAs), but it is also known for producing harmful mycotoxins. However, the genetic capacity for the whole arsenal of natural compounds and their role in the fungus' interaction with rice remained unknown. Here, we...
Resource Type:: Article
Full Text:: Kleigrewe3, Till Bald4, Brenda D. Wingfield7, Ron Ophir8, Stanley Freeman9, Michael Hippler4, Kristina M

ScholarsArchive@OSU

The Fusarium graminearum Histone H3 K27 Methyltransferase KMT6 Regulates Development and Expression of Secondary Metabolite Gene Clusters

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Chromatin structural changes around satellite repeats on the female sex chromosome in Schistosoma mansoni and their possible role in sex chromosome emergence

Heterokaryon Incompatibility Is Suppressed Following Conidial Anastomosis Tube Fusion in a Fungal Plant Pathogen

Genes Related to Ion-Transport and Energy Production Are Upregulated in Response to CO₂-Driven pH Decrease in Corals: New Insights from Transcriptome Analysis

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

The putative protein methyltransferase LAE1 controls cellulase gene expression in Trichoderma reesei

Functional Analyses of Trichoderma reesei LAE1 Reveal Conserved and Contrasting Roles of This Regulator

Deciphering the Cryptic Genome: Genome-wide Analyses of the Rice Pathogen Fusarium fujikuroi Reveal Complex Regulation of Secondary Metabolism and Novel Metabolites

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