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Filtering by: Creator Hindmarsh, R. Remove constraint Creator: Hindmarsh, R. Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Kinetic analysis of avian sarcoma virus integrase in the presteady-state

    Creator:
    Bao, Kogan K.
    Abstract:
    Integrase catalyzes insertion of a retroviral genome into the host chromosome. Following reverse transcription, integrase binds specifically to the ends of the duplex retroviral DNA, endonucleolytically cleaves two nucleotides from each 3'-end (the processing activity), and inserts these ends into the host DNA (the joining activity) in a concerted manner....
    Resource Type:
    Dissertation
    Full Text:
    : U3, R, and U5. Because the two LTRs are oriented in the same direction within the reverse

  • Modulation of deoxyribonucleoside triphosphate levels, DNA synthesis rates and fidelity in mammalian cells

    Creator:
    Martomo, Stella A.
    Abstract:
    Deoxyribonucleoside triphosphate (dNTP) concentrations measured in cells are not symmetric. dGTP almost always represents only 5-10% of the total dNTP pools in cells. In an in vitro replication system involving semiconservative replication from an SV 40 origin, the mutation frequency of an M13 phagemid replicated by human cell extracts in...
    Resource Type:
    Dissertation
    Full Text:
    .. ,.methYlene-THF dTMPsynthase r THF Al? 4, DHF NDP dTMP UI-IF reductase ATP I dTMP kinase4( dTDP ATP NOP