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Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation
Full Text:: , along with H. yunnanensis Hu. and H. japonicus Siebold & Zucc. (synonymous with Humulus scandens (Lour

Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

Creator:: Porter, Joseph J.
Abstract:: The buildup of reactive oxygen species (ROS) and reactive nitrogen and oxygen species (RNS) is known as oxidative stress. Oxidative stress results in a wide variety of modification to biological macromolecules including nucleic acids, lipids, and proteins. For at least 30 years it has been known that high levels of...
Resource Type:: Dissertation

Building a bridge from chromosomes to microtubules in Neurospora crassa

Creator:: Friedman, Steven
Abstract:: DNA is often described as the “blueprint for life”. In eukaryotes this information is contained within linear chromosomes of varying size and number. During cell division, the chromosomes must be faithfully segregated into each daughter cell to avoid disease and sustain life. This process is carried out by the kinetochore...
Resource Type:: Dissertation

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation

Peroxiredoxins in Parasites

Creator:: Gretes, Michael C., Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Significance: Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. Recent Advances: Plasmodial and...
Resource Type:: Article

Intramolecular and intermolecular strand hybridization during adenovirus DNA replication

Creator:: Xu, Fu-yun
Abstract:: Adenovirus initiates strand-displacement DNA replication from origins located in identical inverted terminal repetitions (ITRs). Panhandle structures, formed by base-pairing between ITRs on the displaced strands, have been proposed as replication intermediates for complementary strand synthesis. Plasmid molecules containing a single adenovirus terminal sequence and specially arranged inverted repeat sequences were...
Resource Type:: Dissertation
Full Text:: , and Chin-Hwa Hu for providing some of the materials and for helping with several experiments. TABLE

Structure and function of chromatin : studies at the nucleosome and nuclear matrix levels

Creator:: Shih, Ah Shing
Abstract:: Several levels of eukaryotic chromatin structure have been observed: the nucleosome, the 10 nm and 30 nm fibers and loop domains, apparently attached to the nuclear matrix. In this research, the structure and function of chromatin at two of these levels was investigated, with studies on both nucleosome positioning and...
Resource Type:: Dissertation
Full Text:: Lang, Valerie Stanik, Feng Dong, Sanford Leuba, Fu Yun Xu, Chin Hwa Hu and the secretaries in the

Structural requirements for adenovirus DNA replication

Creator:: Hu, Chin-Hwa
Abstract:: The adenovirus replication origins reside in the inverted terminal repetition (ITR) sequences. Replication proceeds unidirectionally by a strand-displacement mechanism from either or both origins to produce duplex daughter DNA plus a displaced parental strand. The displaced strand can be duplicated by two different routes. The cis pathway involves intramolecular hybridization...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE THESIS OF Chin-Hwa Hu, for the degree of Doctor of Philosophy in Biochemistry and

Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism

Creator:: Schmidt, Edward Eric
Resource Type:: Dissertation

Sequence conversion during adenovirus DNA replication

Creator:: Bennett, Kelly L.
Abstract:: The work in this thesis has provided conclusive genetic evidence that "panhandle" intermediates form during adenovirus replication. Adenovirus chromosomes lacking 51 by from their left -hand termini are infectious and capable of regenerating the missing origin sequence. Yet if an entire inverted terminal repeat is removed, the adenovirus chromosome is...
Resource Type:: Dissertation
Full Text:: very special thanks to Dr. Chin-Hwa Hu for his completely altruistic approach in the laboratory. I

ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Defining the Role of Tyrosine Nitration in Biology with Genetic Code Expansion

Building a bridge from chromosomes to microtubules in Neurospora crassa

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Peroxiredoxins in Parasites

Intramolecular and intermolecular strand hybridization during adenovirus DNA replication

Structure and function of chromatin : studies at the nucleosome and nuclear matrix levels

Structural requirements for adenovirus DNA replication

Repression of dihydrofolate reductase synthesis during myogenesis : identification and characterization of a transcriptional regulatory mechanism

Sequence conversion during adenovirus DNA replication

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