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Filtering by: Creator Joerger, Verena M. Academic Affiliation Biochemistry and Biophysics

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Creator:

Breysse, Daniel H.

Abstract:

Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...

Resource Type:

Masters Thesis

Full Text:

(Fig. 3) (Boucek et al., 1987; Joerger et al., 2005; Olson et al., 1988). Doxol has been shown to be