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Creator:: Wiemann, Philipp, Sieber, Christian M. K., von Bargen, Katharina W., Studt, Lena, Niehaus, Eva- Maria, Espino, Jose J., Huß, Kathleen, Michielse, Caroline B., Albermann, Sabine, Wagner, Dominik, Bergner, Sonja V., Connolly, Lanelle R., Fischer, Andreas, Reuter, Gunter, Kleigrewe, Karin, Bald, Till, Wingfield, Brenda D., Ophir, Ron, Freeman, Stanley, Hippler, Michael, Smith, Kristina M., Brown, Daren W., Proctor, Robert H., Munsterkotter, Martin, Freitag, Michael, Humpf, Hans-Ulrich, Guldener, Ulrich, and Tudzynski, Bettina
Abstract:: The fungus Fusarium fujikuroi causes "bakanae" disease of rice due to its ability to produce gibberellins (GAs), but it is also known for producing harmful mycotoxins. However, the genetic capacity for the whole arsenal of natural compounds and their role in the fungus' interaction with rice remained unknown. Here, we...
Resource Type:: Article
Full Text:: Novel Metabolites Philipp Wiemann1.¤, Christian M. K. Sieber2., Katharina W. von Bargen3., Lena Studt1,3

Creator:: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Leonova, Katerina I., Wawrzyniak, Joseph A., Bianchi-Smiraglia, Anna, Berman, Albert E., Flanagan, Sheryl, Shewach, Donna S., Zeitouni, Nathalie C., Gudkov, Andrei V., Mathews, Christopher K., and Nikiforov, Mikhail A.
Abstract:: The down‐regulation of dominant oncogenes, including C‐MYC, in tumor cells often leads to the induction of senescence via mechanisms that are not completely identified. In the current study, we demonstrate that MYC‐depleted melanoma cells undergo extensive DNA damage that is caused by the underexpression of thymidylate synthase (TS) and ribonucleotide...
Resource Type:: Article
Full Text:: that depletion of C- MYC in human melanoma cells led to the induction of senescence-associated

Creator:: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Natarajan, Venkatesh, Zucker, Shoshanna N., Fink, Emily E., Im, Michael, Flanagan, Sheryl, Burhans, William C., Zeitouni, Nathalie C., Shewach, Donna S., Mathews, Christopher K., and Nikiforov, Mikhail A.
Abstract:: In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...
Resource Type:: Article
Full Text:: Undergoing Oncogene-Induced Senescence Sudha Mannava 1 , Kalyana C. Moparthy 1 , Linda J. Wheeler 4

Creator:: Chimploy, Korakod, Song, Shiwei, Wheeler, Linda J., and Mathews, Christopher K.
Abstract:: Deoxyribonucleoside triphosphate pools in mammalian mitochondria are highly asymmetric, and this asymmetry probably contributes toward the elevated mutation rate for the mitochondrial genome as compared with the nuclear genome. To understand this asymmetry, we must identify pathways for synthesis and accumulation of dNTPs within mitochondria. We have identified ribonucleotide reductase...
Resource Type:: Article
Full Text:: Press, Washington, DC 34. Kukat, C., Wurm, C. A., Spåhr, H., Falkenberg, M., Larsson, N-G., and

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