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Filtering by: Creator Le Direach, Laurence Remove constraint Creator: Le Direach, Laurence Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Conformational changes in histone IV as induced by salts and nucleoside triphosphates

    Creator:
    Wickett, Richard Randall
    Abstract:
    The addition of salts or nucleoside triphosphates to histone IV solutions induces conformational changes in the histone molecule. These conformational changes are investigated by measurement of the fluorescence anisotropy of the histone tyrosine emission, the circular dichroism (CD) of the peptide bond and of the tyrosine CD. Changes induced by...
    Resource Type:
    Dissertation
    Full Text:
    (Hnilica, Johns and Butler, 1962; Hnilica, 1966; Laurence et al., 1963, 1966; Johns, 1971), argues against

  • Monophoton decay time fluorometry : theory, design, and application to biochemical systems

    Creator:
    Schuyler, Robert John
    Abstract:
    In the determination of binding heterogeneity and rotational diffusion relaxation times, fluorescence decay curves often take the form of sums of exponential decay times. An instrument is described which includes features permitting the collection of high precision time decay data, which may successfully be resolved into component decays. The instrument...
    Resource Type:
    Dissertation
    Full Text:
    in water and when adsorbed to proteins (Weber and Laurence, 1954). A result of this observation is

  • Physical studies of the yeast inner histones

    Creator:
    Mardian, James Kenneth Walker
    Abstract:
    In this work, the four yeast inner histones were prepared by the use of consecutive slab gel fractionation. The use of this technique allowed the first complete fractionation and rigorous identification of the four yeast inner histones, and made possible a study of their complexing behavior. Variants and adjuncts of...
    Resource Type:
    Dissertation
    Full Text:
    , 1958; Laurence, 1966; Davison and Shooter, 1956; Mauritzen and Stedman, 1959; Phillips, 1965, 1967

  • Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

    Creator:
    Otto, Shauna C.
    Abstract:
    Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
    Resource Type:
    Dissertation
    Full Text:
    how Ca2+ binding can alter the properties of the domain. 9 T ab le 1. 1: C al ci u m b in d in