Index Catalog // ScholarsArchive@OSU

Environmental influences on monoterpenes and phenolics of Mentha piperita

Creator:: Yao, Cheng C.
Abstract:: Vegetatively propagated peppermint (Mentha piperita L., cv. Black Mitcham) was used to determine the effects of night temperatures (8°C vs 25°C) on the plant growth in terms of fresh weight and leaf area, and on metabolite contents. The plants were sampled after 14 days, 21 days and 28 days in...
Resource Type:: Masters Thesis
Full Text:: Mentha piperita AN ABSTRACT OF THE THESIS OF Cheng C. Yao for the degree of Master of Science in

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: AN ABSTRACT OF THE DISSERTATION OF Chuan Li for

Interplay between HIV-1 infection and host microRNAs

Creator:: Sun, Guihua, Li, Haitang, Wu, Xiwei, Covarrubias, Maricela, Scherer, Lisa, Meinking, Keith, Luk, Brian, Chomchan, Pritsana, Alluin, Jessica, Gombart, Adrian F., and Rossi, John J.
Abstract:: Using microRNA array analyses of in vitro HIV-1-infected CD4(+) cells, we find that several host microRNAs are significantly up- or downregulated around the time HIV-1 infection peaks in vitro. While microRNA-223 levels were significantly enriched in HIV-1-infected CD4(superscript+)CD8(superscript-) PBMCs, microRNA-29a/b, microRNA-155 and microRNA-21 levels were significantly reduced. Based on the...
Resource Type:: Article

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Peroxiredoxins in Parasites

Creator:: Gretes, Michael C., Poole, Leslie B., and Karplus, P. Andrew
Abstract:: Significance: Parasite survival and virulence relies on effective defenses against reactive oxygen and nitrogen species produced by the host immune system. Peroxiredoxins (Prxs) are ubiquitous enzymes now thought to be central to such defenses and, as such, have potential value as drug targets and vaccine antigens. Recent Advances: Plasmodial and...
Resource Type:: Article
Full Text:: G ia rd ia la m b li a P rx 1a G L 5 0 8 0 3 _ 1 4 5 2 1 (2 ) P rx 1b G L 5 0 8 0

Cloning and characterization of polyketide biosynthetic gene clusters from Streptomyces murayamaensis, Streptomyces rimosus, and Streptomyces WP 4669

Creator:: Hong, Seong-tshool
Resource Type:: Dissertation
Full Text:: , S. J., Cheng, X. C. and K. A. Halley. 1992. Biosynthesis of dehydrorabelomycin and PD 116740

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Creator:: Ding, Jun
Abstract:: The studies described in this thesis were motivated by ongoing efforts to develop lignocellulosic biomass as an efficient and practical source of renewable energy. Enormous problems complicate these efforts to reduce reliance on greenhouse gas-generating fossil fuels. Simply obtaining the fermentable sugars available in the cellulose and hemicellulose components of...
Resource Type:: Dissertation
Full Text:: and other metabolites, and regulation of osmotic balance and pH (Li and Kane, 2009). Loss of V

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Creator:: Breysse, Daniel H.
Abstract:: Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...
Resource Type:: Masters Thesis
Full Text:: homeostasis and antioxidant stress response (Cheng et al., 2012; Ebert et al., 2010; Hu et al., 2006

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Creator:: Hooven, Louisa Ada
Abstract:: Exposure to polycyclic aromatic hydrocarbons such as benzo[a]pyrene (B[a]P) has been determined to be a risk factor for various forms of human cancer. PAH DNA adducts have been shown to cause mutations, but carcinogenesis is also accompanied by alterations in gene expression. Inhibiting individual cytochrome P450s could clarify the interaction...
Resource Type:: Dissertation

Rapid kinetic studies of thymidylate synthase

Creator:: Mittelstaedt, Denice
Resource Type:: Dissertation
Full Text:: versus li[dUMP] at constant 5,10-CH2H4folate concentrations using thymidylate synthase previously

ScholarsArchive@OSU

Environmental influences on monoterpenes and phenolics of Mentha piperita

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Interplay between HIV-1 infection and host microRNAs

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Peroxiredoxins in Parasites

Cloning and characterization of polyketide biosynthetic gene clusters from Streptomyces murayamaensis, Streptomyces rimosus, and Streptomyces WP 4669

In vivo detoxification of acetic acid in Saccharomyces cerevisiae

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

DNA binding and beyond : an investigation of proteins involved in PAH-induced carcinogesesis

Rapid kinetic studies of thymidylate synthase

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