Index Catalog // ScholarsArchive@OSU

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Creator:: Vanegas, Juan Manuel
Abstract:: The unfolding of human retinoid X receptor α in the presence of the denaturant guanidine HCl was studied using stopped-flow absorbance spectroscopy. The protein's four native cysteine residues were mutated to obtain four single-cysteine mutants, each with the other three cysteine residues mutated to alanine. The thiols of these hRXRα...
Resource Type:: Masters Thesis

Helical propensity of amino acids changes with solvent environment

Creator:: Krittanai, Chartchai
Resource Type:: Dissertation
Full Text:: committee members, Dr. Pui Shing Ho, Dr. Victor L. Hsu, Dr. Joseph W. Nib ler, and Dr. Carol J. Rivin for

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Creator:: Hanson, Eric Scott
Resource Type:: Dissertation
Full Text:: . Lastly, I thank the members of my committee, Drs. Christopher Mathews, Douglas Barofsky, Shing Ho, Jo-Ann

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Creator:: Hendricks, Stephen P.
Abstract:: The first committed step in DNA biosynthesis occurs by direct reduction of ribonucleotides. This reduction is catalyzed by ribonucleotide reductase (RNR), an enzyme which uses a unique radical mechanism to facilitate the transformation. All four DNA precursors are synthesized by a single enzyme. Therefore, an intricate pattern of regulation has...
Resource Type:: Dissertation
Full Text:: members, Drs. Pui Shing Ho, Victor L. Hsu, William H. Gerwick, and Russel H. Meints for the time and

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: 2 (Nrf2) activation, increased mRNA and protein levels of heme oxygenase 1 (HO-1), NAD(P)H

Cytoskeletal regulation in cell motility and invasion

Creator:: Jang, Hyo Sang
Abstract:: Cell motility and invasion are important for development, immunity, wound healing, and tumor cell metastasis. Cells on two dimensional substrates migrate in three steps: protrusion of the front end, translocation of the cell body, and retraction of the rear end. For cells to migrate efficiently, these steps need to be...
Resource Type:: Dissertation
Full Text:: thanks to my wife Soo Jin Lee for her continuous support and inspiration, and my two daughters April

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Creator:: Breysse, Daniel H.
Abstract:: Doxorubicin is a widely used cancer therapeutic, but its effectiveness is limited by cardiotoxic side effects. Evidence suggests cardiotoxicity is due not to doxorubicin, but rather its metabolite, doxorubicinol. Identification of the enzymes responsible for doxorubicinol formation is important in developing strategies to prevent cardiotoxicity. In this study, the contributions...
Resource Type:: Masters Thesis
Full Text:: ; Jin and Penning, 2007; Kassner et al., 2008; Morikawa et al., 2015; Sonowal et al., 2017). 1.2

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

Creator:: Vulpanovici, Florina Alexandra
Abstract:: This thesis details investigations of marine cyanobacterial secondary metabolism, with emphasis on a strain of Phormidium sp. collected in Indonesia. These studies assessed the effects of nineteen putative elicitor compounds on the growth and metabolite production of five species of marine cyanobacteria, biosynthetic investigation of an intriguing secondary metabolite, phormidolide,...
Resource Type:: Dissertation
Full Text:: N'LJN N ON 0 N N ON HO-1Oj HOHO-1 HOL. OH OH OH OH Spongouridine (1) Spongothymidine (2) Ara-A (3) Ara

ScholarsArchive@OSU

Alkylation kinetics of the human retinoid X receptor α using cysteine as a local probe

Helical propensity of amino acids changes with solvent environment

Bacteriophage T4 ribonucleotide reductase : genes and proteins

Regulation of ribonucleotide reductase analyzed by simultaneous measurement of the four enzyme activities

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Cytoskeletal regulation in cell motility and invasion

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Identifying the Enzymes Responsible for Reduction of Doxorubicin to its Cardiotoxic Metabolite Doxorubicinol using a Novel Immunoclearing Approach

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Biosynthesis, production and structural studies of secondary metabolites in cultured marine cyanobacteria

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