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Filtering by: Creator McCarty, Dennis Remove constraint Creator: McCarty, Dennis Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • In vitro transcription in the yeast: Saccharomyces cerevisiae

    Creator:
    Ide, Gregory James
    Abstract:
    The structure and transcriptional activity of intranuclear and isolated chromatin from logarithmically growing yeast cells has been compared to chromatin from cells which have entered the stationary phase and ceased growing. Both chromatins show a similar nucleosomal repeat pattern and a 160 by repeat size when digested with staphlococcal nuclease....
    Resource Type:
    Dissertation
    Full Text:
    thank Dennis Lohr for the collaboration which resulted in Chapter I of this thesis, and for data on

  • Physical structure and reconstitution of chromatin core particles

    Creator:
    Tatchell, Kelly George
    Abstract:
    The nucleosome appears to be the basic structural unit of the eukaryotic chromosome. The usual nucleosome preparation, isolated from a micrococcal nuclease digest of nuclei, is heterogenous in DNA length and protein composition with some particles containing spacer DNA and associated protein. This heterogeneity complicated physical and reconstitution studies. As...
    Resource Type:
    Dissertation
    Full Text:
    interest and advice in this project. Drs. Barbara Shaw, Dennis Lohr, David Lilley, Wolfgang Weischet

  • The effects of hexachlorophene on mitochondrial and artificial membrane systems

    Creator:
    Ramberg, Donald Allen
    Abstract:
    Hexachlorophene (HCP; 2,2'-methylenebis-(3,4,6-trichlorophenol)) was developed as an antibacterial agent but was also found to induce toxic effects in various tissues in animals and humans. Changes were found in myelinated nerve fibers and cerebral white matter. Erythrocytes are hemolysed in vitro. Oxidative phosphorylation is uncoupled by HCP at concentrations less than...
    Resource Type:
    Dissertation
    Full Text:
    subsequently found with these topically applied preparations (St. Dennis and Nagata, 1972). These and other

  • Physical studies of the yeast inner histones

    Creator:
    Mardian, James Kenneth Walker
    Abstract:
    In this work, the four yeast inner histones were prepared by the use of consecutive slab gel fractionation. The use of this technique allowed the first complete fractionation and rigorous identification of the four yeast inner histones, and made possible a study of their complexing behavior. Variants and adjuncts of...
    Resource Type:
    Dissertation
    Full Text:
    , Robert Becker, and Kensal Van Ho lde for the use of their instruments and discussions; Drs. Dennis Lohr