Index Catalog // ScholarsArchive@OSU

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation
Full Text:: Signaling Abstract approved: ______________________________________________________ Afua A

The function and structural characteristics of conserved regions within Escherichia Coli small subunit ribosomal RNA

Creator:: Almehdi, Mirza A.
Abstract:: Ribosomes are multicomponent macromolecular particles and are essential for the survival of cells in all organisms. The ribosome's universal function is to catalyze polypeptide synthesis through translation of mRNA transcripts. Ribosomes from Escherichia coli, eubacterial organisms, have a sedimentation coefficient of 70S and are composed of 30S and 50S ribonucleoprotein...
Resource Type:: Dissertation
Full Text:: regions within Escherichia Coli small subunit ribosomal RNA AN ABSTRACT OF THE THESIS OF Mirza A

Analyses of noncanonical DNA structures

Creator:: Khuu, Patricia A.
Abstract:: The structural polymorphic nature of DNA has been long been recognized since the model of the right-handed B-DNA duplex proposed by James Watson and Francis Crick was accepted. Its malleability is thought to be critical in protein recognition and manipulation. In particular, it can form Holliday junctions, four-way DNA structural...
Resource Type:: Dissertation
Full Text:: Patricia A. Khuu for the degree of Doctor of Philosophy in Biochemistry and Biophysics presented on June

In vivo phosphorylation of phosphofructokinase at a novel site

Creator:: Harrahy, John J.
Abstract:: This thesis examines the interconnection between the in vitro and in vivo phosphorylation of rabbit muscle phosphofructokinase. The first goal of the project was to show whether a novel site of rabbit muscle phosphofructokinase that is subject to in vitro phosphorylation, serine 376, may also become phosphorylated in vivo. Evidence...
Resource Type:: Dissertation
Full Text:: Phosphorylation of Phosphofructokinase at a Novel Site. Abstract approved: Sonia R. Anderson This thesis

Biophysical analyses of peroxiredoxins and a partner reductase

Creator:: Hall, Andrea Renée
Abstract:: Peroxiredoxins (Prxs) are dominant peroxide-reducing enzymes with two important roles: they protect all organisms from oxidative damage induced by peroxides, and in eukaryotes, they participate in hydrogen peroxide signaling pathways. This dissertation presents studies aimed at the biophysical characterization of select Prxs and a Prx reductase to elucidate their structure-function...
Resource Type:: Dissertation
Full Text:: presented on May 10, 2010 Title: . Biophysical Analyses of Peroxiredoxins and a Partner Reductase

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Creator:: Wang, Yizhou, Smith, Kristina M., Taylor, John W., Freitag, Michael, and Stajich, Jason E.
Abstract:: Genome defense likely evolved to curtail the spread of transposable elements and invading viruses. A combination of effective defense mechanisms has been shown to limit colonization of the Neurospora crassa genome by transposable elements. A novel DNA transposon named Sly1-1 was discovered in the genome of the most widely used...
Resource Type:: Article
Full Text:: Endogenous Small RNA Mediates Meiotic Silencing of a Novel

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation
Full Text:: and Biophysics presented on March 11, 2021. Title: Towards a Better Understanding of How the

Stabilization of Z-DNA by demethylation of thymine bases : a crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG)

Creator:: Zhou, Guangwen
Resource Type:: Dissertation
Full Text:: : a crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG) AN ABSTRACT OF THE THESIS OF Guangwen

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Creator:: Mustacich, Debbie J.
Resource Type:: Dissertation
Full Text:: Microtubule System and the Canalicular mdr2 P-glycoprotein Play a Role in the Intracellular Transport and

Analysis of ras gene mutations in rainbow trout tumors

Creator:: Chang, Yung-jin
Abstract:: For ras gene mutation analysis in the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified using the polymerase chain reaction (PCR). Two synthetic oligonucleotides based on rat K-ras gene sequence were used as primers for the PCR procedure. A 90 base pair (bp) sequence, referred...
Resource Type:: Dissertation
Full Text:: the rainbow trout (Oncorhynchus mykiss) model system, a partial trout ras sequence was identified

ScholarsArchive@OSU

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

The function and structural characteristics of conserved regions within Escherichia Coli small subunit ribosomal RNA

Analyses of noncanonical DNA structures

In vivo phosphorylation of phosphofructokinase at a novel site

Biophysical analyses of peroxiredoxins and a partner reductase

Endogenous Small RNA Mediates Meiotic Silencing of a Novel DNA Transposon

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Stabilization of Z-DNA by demethylation of thymine bases : a crystallization and thermo-dynamic study of d(m⁵CGUAm⁵CG)

The microtubule system and the canalicular mdr2 P-glycoprotein play a role in the intracellular transport and biliary secretion of α-Tocopherol and phosphatidylcholine in rats and mice

Analysis of ras gene mutations in rainbow trout tumors

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