Index Catalog // ScholarsArchive@OSU

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation
Full Text:: THE DISSERTATION OF Kasie J. Baker for the degree of Doctor of Philosophy in Biochemistry and

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Creator:: Logan, Isabelle E.
Abstract:: Xanthohumol, a prenylated flavonoid found in hops and beer, possesses a long-standing reputation to improve health. Xanthohumol’s cytotoxicity to a wide variety of cancer cell lines is well-established. Herein we provide further insight into the cytotoxicity of not only xanthohumol, but also its non-estrogenic derivatives, to a number of colonic...
Resource Type:: Dissertation

Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

Creator:: Jespersen, Nathan E.
Abstract:: As obligate intracellular parasites, viruses rely on host machinery for their own reproduction. Viruses are therefore required to interact with a wide variety of host proteins, despite limitations in viral genome size. The most parsimonious method of success is to hijack central and essential proteins, known as hub proteins. LC8...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Elisar J. Barbar As

Nucleosome instabilities in physiological salt

Creator:: Yager, Thomas D.
Abstract:: Best scan available for figures. Some figures are high gloss photos, others are black and white photocopies.
Resource Type:: Dissertation
Full Text:: , criticism and advice: G. Ackers, K. Ahern, G. Bailey, E.M. Bradbury, D. Brooker, J. Davie, H. Eisenberg, E

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Creator:: Beilby, Pamela R.
Abstract:: Amyotrophic lateral sclerosis (ALS) is a devastating neurological disorder characterized by neuromuscular junction decay, motor neuron death, progressive paralysis, and eventually death of the individual, usually by respiratory failure. Oxidative stress is a prominent hallmark of the disease and is often accompanied and exacerbated by mitochondrial dysfunction and neuroinflammation. This...
Resource Type:: Dissertation

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation
Full Text:: : _____________________________________________________ Elisar J. Barbar Intrinsically disordered proteins (IDP) are a class of proteins that lack

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Creator:: Jie, Jing, Löhr, Frank, and Barbar, Elisar
Abstract:: Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
Resource Type:: Article
Full Text:: , O., Delaglio, F., Rossi, P., Aramini, J. M., Liu, G., Eletsky, A., Wu, Y., Singarapu, K. K., Lemak

Studies on the inhibition of bovine plasma amine oxidase by hydrazines

Creator:: Hucko-Haas, Jacqueline Elizabeth
Abstract:: Several aspects of the potent inhibition of bovine plasma amine oxidase (PAO) by hydrazines were investigated by kinetic and preparative means. The inhibition was classified as pseudo-irreversible by the method of Ackerman and Potter (Proc. Soc. Exptl. Biol. Med. 72, 1 (1949), and was found to exhibit Zone B kinetic...
Resource Type:: Dissertation
Full Text:: Privacy Dr. Donald J. Reed Several aspects of the potent inhibition of bovine plasma amine oxidase (PAO

Monophoton decay time fluorometry : theory, design, and application to biochemical systems

Creator:: Schuyler, Robert John
Abstract:: In the determination of binding heterogeneity and rotational diffusion relaxation times, fluorescence decay curves often take the form of sums of exponential decay times. An instrument is described which includes features permitting the collection of high precision time decay data, which may successfully be resolved into component decays. The instrument...
Resource Type:: Dissertation
Full Text:: Abstract approved: Irvin Isenberg (j In the determination of binding heterogeneity and rotational

Hemoglobin-binding proteins in the amphibian Taricha granulosa

Creator:: Francis, Ralph T.
Abstract:: The first reported observation of hemoglobin association with a plasma protein was made by Polonovski and Jayle in 1938. Since that time, countless investigators have contributed to the characterization of the hemoglobin- binding plasma protein, haptoglobin. Haptoglobins have been found in many mammals, including humans and in various birds. However,...
Resource Type:: Dissertation

ScholarsArchive@OSU

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Towards a Better Understanding of How the Dietary Supplement Xanthohumol Can Improve Health

Viral Targeting of Host Hubs: Interactions between the Rabies Virus and LC8

Nucleosome instabilities in physiological salt

Oxidative stress in amyotrophic lateral sclerosis : the role of cellular senescence and glutathione

Protein Disorder in the Evolution of Dynein Regulation

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Studies on the inhibition of bovine plasma amine oxidase by hydrazines

Monophoton decay time fluorometry : theory, design, and application to biochemical systems

Hemoglobin-binding proteins in the amphibian Taricha granulosa

Limit your search

Academic Affiliation

Advisor

Commencement Year

Committee Member

Creator

Contributor

Date

Decade

Degree Field

Degree Level

Degree Name

File Format

Language

License

Location

Non-Academic Affiliation

Peer Reviewed

Resource Type

Rights Statement

Subject

Search Constraints

Search Results

Limit your search