Index Catalog // ScholarsArchive@OSU

Subunit structure of Cancer magister Hemocyanin

Creator:: Carpenter, Donald Ellis
Resource Type:: Dissertation
Full Text:: CANCER MAGISTER HEMOC YANIN Abstract approved: Redacted for Privacy K. E. Van Ho lde The molecular

Depletion of Deoxyribonucleotide Pools is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

Creator:: Mannava, Sudha, Moparthy, Kalyana C., Wheeler, Linda J., Natarajan, Venkatesh, Zucker, Shoshanna N., Fink, Emily E., Im, Michael, Flanagan, Sheryl, Burhans, William C., Zeitouni, Nathalie C., Shewach, Donna S., Mathews, Christopher K., and Nikiforov, Mikhail A.
Abstract:: In normal human cells, oncogene-induced senescence (OIS) depends on induction of DNA damage response (DDR). Oxidative stress and hyper-replication of genomic DNA have been proposed as major causes of DNA damage in OIS cells. Here we report that down-regulation of deoxyribonucleoside pools is another endogenous source of DNA damage in...
Resource Type:: Article
Full Text:: , Cimprich KA, Taya Y, Tamai K, Sakaguchi K, Appella E, Kastan MB, Siliciano JD: Activation of the ATM

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Creator:: Perkins, Arden
Abstract:: Peroxiredoxin (Prx) enzymes catalyze the reduction of hydrogen peroxide, peroxynitrous acid, and organic peroxides, and are extremely efficient peroxidases, with k[subscript cat]/K[subscript M] on the order of 10⁷ - 10⁸ M⁻¹ s⁻¹. Besides their role in oxidative stress defense, evidence has accumulated that some eukaryotes, including humans, use Prxs as...
Resource Type:: Dissertation

Kinetics of synthesis and degradation of chicken liver xanthine dehydrogenase

Creator:: Epstein, Arnold
Abstract:: The role of synthesis and degradation in controlling enzyme concentrations was studied. Concentrations of chloride and arginine were determined for blood and liver at various stages of development from the embryo to the 8 day old chicken. The chloride concentrations were used to obtain the volume of extracellular blood in...
Resource Type:: Dissertation
Full Text:: Sakaguchi reaction by creatinine. 29 IV. Arginine and. valine pool sizes in liver and blood in the chick

Adenovirus complementary strand synthesis in vivo

Creator:: Wang, Kai, 1955-
Abstract:: Replication of plasmid molecules containing a single adenovirus terminal sequence and specially arranged inverted repeat sequences were studied. When the plasmids were linearized to expose the adenovirus terminal sequence and transfected into 293 cells with helper adenovirus DNA, a larger molecule was detected. The new molecule contained adenovirus terminal sequences...
Resource Type:: Dissertation
Full Text:: (position 10,767 in type 2; position 10,611 in type 7 (K. G. Ahern, personal communication)), in the

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation
Full Text:: g p ro p er ti es of se le ct P K C C 2 d om ai n s D o m a in N o . C a 2 + A ffi n it y K

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Creator:: Codding, Sara Jone
Abstract:: The focus of this dissertation was to understand protein function and structure ona molecular level. To do this successfully, a variety of biochemical and biophysicaltechniques were employed. A wide variety of techniques were applied to study theproteins of interest in this dissertation to probe protein-protein interactions, proteinfunction, protein structure, and...
Resource Type:: Dissertation
Full Text:: Padmanarayana for our friendly conversations, and Naomi J. Marty, for always reminding me that life is short

Characterization of different forms of lysophospholipase in barley

Creator:: Lundgard, Robert
Abstract:: During barley germination, α-amylase and other hydrolases are synthesized in the aleurone layer and secreted into the starchy endosperm. As starch is degraded by amylases, lysophospholipids are released from inclusion complexes with the starch and undergo hydrolysis by a lysophospholipase (LPL) activity. Studies with embryo-free half seeds and isolated aleurone...
Resource Type:: Dissertation
Full Text:: -37. 79. Motojuma, K. and Sakaguchi, K. (1982) Part of the lysyl residues in wheat a-amylase is

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

Creator:: Jensen, Ole Norregaard
Abstract:: A novel protocol for the study of protein-nucleic acid interactions is presented and demonstrated to be feasible. The protocol combines photochemical crosslinking techniques and mass spectrometric methods into a new strategy for identifying protein domains or amino acid residues that are in close contact with nucleic acid in protein-nucleic acid...
Resource Type:: Dissertation

ScholarsArchive@OSU

Subunit structure of Cancer magister Hemocyanin

Depletion of Deoxyribonucleotide Pools is an Endogenous Source of DNA Damage in Cells Undergoing Oncogene-Induced Senescence

Model systems for structural investigations into peroxiredoxin catalysis, conformation change, and inactivation

Kinetics of synthesis and degradation of chicken liver xanthine dehydrogenase

Adenovirus complementary strand synthesis in vivo

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Functional and Structural Analyses of Three Distinct proteins by Biochemical and Biophysical Techniques

Characterization of different forms of lysophospholipase in barley

Protein Disorder in the Evolution of Dynein Regulation

Characterization of photochemically cross-linked protein-nucleic acid complexes by mass spectrometry

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