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Filtering by: Creator Sayavedra-Soto, Luis A. Academic Affiliation Biochemistry and Biophysics

Mitochondrial decay in the aging rat heart : changes in fatty acid-supported bioenergetics and macromolecular organization of the electron transport system

Creator:

Gómez Ramirez, Luis A.

Abstract:

Decline in cardiac pump function is a hallmark of aging where mitochondrial decay is an important underlying cause. Although certainly multifactorial in nature, both dysfunction of the machinery involved in the chemiosmotic process of energy transduction and lower capacity to maintain fatty acid-driven respiration are identified as intrinsic factors of...

Resource Type:

Dissertation

Full Text:

AN ABSTRACT OF THE DISSERTATION OF Luis A. Gómez for the degree of Doctor of Philosophy in
Nitric oxide-mediated oxidative damage and the progressive demise of motor neurons in ALS

Creator:

Drechsel, Derek A., Estevez, Alvaro G., Barbeito, Luis, and Beckman, Joseph S.

Abstract:

Oxidative damage is a common and early feature of Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis (ALS) and other neurodegenerative disorders. Dr. Mark Smith and his colleagues have built the case for oxidative stress being a primary progenitor rather than a secondary end-stage epiphenomenon of neurodegeneration. They proposed that reactive...

Resource Type:

Article

Full Text:

the progressive demise of motor neurons in ALS Derek A. Drechsel a,b , Alvaro G. Estévez c