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Filtering by: Creator Schuck, Sarah Remove constraint Creator: Schuck, Sarah Academic Affiliation Biochemistry and Biophysics Remove constraint Academic Affiliation: Biochemistry and Biophysics

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  • Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

    Creator:
    Baker, Kasie J.
    Abstract:
    The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
    Resource Type:
    Dissertation
    Full Text:
    Sav. Rather the formation of the Hpo-Sav complex is mediated by the SARAH domains present in both