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Filtering by: Committee Member Spinrad, B. I. Academic Affiliation Biochemistry and Biophysics

Control of p53 tumor suppressor and peroxiredoxin activity through shifts incellular redox balance

Creator:

Stoner, Christopher S.

Abstract:

Aerobic organisms have evolved many sensory mechanisms that allow response to oxidants in the environment. One area of interest is the relationship between the activity of the tumor suppressor protein p53 and the redox state of thioredoxin. Human p53 activity is severely compromised in budding yeast lacking thioredoxin reductase. Evidence...

Resource Type:

Dissertation

Full Text:

formation with members of the inhibitor of kappa B (IκB) family. IκB-binding activity is in turn 4