Index Catalog // ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Creator:: Padgitt-Cobb, Lillian K.
Abstract:: Hop (Humulus lupulus L. var. lupulus) is a diploid, dioecious plant with an extensive history of cultivation and use in brewing, as a textile, and for its therapeutic properties. Hop is prized for its ability to produce a variety of aromatic and flavor compounds, as well as compounds with anti-microbial...
Resource Type:: Dissertation

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Creator:: Li, Chuan
Abstract:: Atherosclerosis is the underlying cause of ischemic heart disease and stroke and is the leading cause of death worldwide, especially in developed countries. As an inflammatory disease of arteries in a hyperlipidemic milieu, expression of adhesion molecules, such as endothelial-leukocyte adhesion molecule-1 (E-selectin) and intercellular adhesion molecule-1 (ICAM-1), on endothelial...
Resource Type:: Dissertation
Full Text:: responses were induced by thrombin in HAEC but not in HUVEC [Wang 1997]. Tissue factor activity was also

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Creator:: Otto, Shauna C.
Abstract:: Dysferlin is a ∼230 kDa terminally anchored membrane protein that is ubiquitously expressed, but is particularly enriched in skeletal and cardiac muscle tissue. Mutations covering the length of the protein have been linked to muscle wasting diseases including limb-girdle muscular dystrophy and Myoshi myopathy. Dysferlin has been shown to play...
Resource Type:: Dissertation

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Creator:: Saldivar, Joshua C., Miuma, Satoshi, Bene, Jessica, Hosseini, Seyed Ali, Shibata, Hidetaka, Sun, Jin, Wheeler, Linda J., Mathews, Christopher K., and Huebner, Kay
Abstract:: Genomic instability drives tumorigenesis, but how it is initiated in sporadic neoplasias is unknown. In early preneoplasias, alterations at chromosome fragile sites arise due to DNA replication stress. A frequent, perhaps earliest, genetic alteration in preneoplasias is deletion within the fragile FRA3B/FHIT locus, leading to loss of Fhit protein expression....
Resource Type:: Article

Protein Disorder in the Evolution of Dynein Regulation

Creator:: Jie, Jing
Abstract:: Intrinsically disordered proteins (IDP) are a class of proteins that lack a three-dimensional structure and their prevalence and diverse functions in the cell have only been discovered relatively recently. The intermediate chain (IC) subunit of the microtubule motor protein complex dynein contains an N-terminal disordered region, N-IC, which is central...
Resource Type:: Dissertation
Full Text:: development (Romero et al., 2006). There are 92–97% of multi- exonic human genes that undergo AS (Wang et al

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Creator:: Jie, Jing, Löhr, Frank, and Barbar, Elisar
Abstract:: Intrinsically disordered protein (IDP) duplexes composed of two IDP chains cross-linked by bivalent partner proteins form scaffolds for assembly of multiprotein complexes. The N-terminal domain of dynein intermediate chain (N-IC) is one such IDP that forms a bivalent scaffold with multiple dynein light chains including LC8, a hub protein that...
Resource Type:: Article
Full Text:: ., Ying, J., and Bax, A. (2012) Measurement of 15N relaxation rates in perdeuterated proteins by TROSY

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Creator:: Fey, Rosalyn M.
Abstract:: Systems biology is a powerful approach which considers and sheds light on all of the puzzle pieces which make up complex biological processes, and is an effective alternative to unraveling these processes using traditional molecular approaches alone. It is a natural companion approach for computational biology, which leverages the power...
Resource Type:: Dissertation

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Creator:: Baker, Kasie J.
Abstract:: The Hippo signaling pathway is an evolutionarily conserved regulator of cell growth, proliferation, and apoptosis. A key function of the pathway is to regulate the subcellular distribution and activity of Yorkie in Drosophila or Yes-associated protein (YAP) and transcription co-activator with PDZ-binding motif (TAZ) in mammals. The dysregulation of the...
Resource Type:: Dissertation

Characterization of the Structure and Dynamics of the Intrinsically Disordered Dynein Intermediate Chain and its Interactions with Regulatory Binding Partners

Creator:: Morgan, Jessica L.
Abstract:: Cells represent microcosms of spatial and temporal structural organization, with the achievement of internal spatial organization relying upon a collection of macromolecular motor complexes to transport and localize components throughout the cell. Cytoplasmic dynein is one such motor complex, and is the principal ATP-dependent motor for retrograde transport along microtubules...
Resource Type:: Dissertation
Full Text:: ! 5 accommodate binding to similar, but topologically distinct, Cdk–cyclin heterodimers (Wang et

Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

Creator:: Vogel, Amber J.
Abstract:: Cell signaling is often mediated by protein-protein interactions, which must be specific, tunable, and transient to allow agile responsiveness to cellular messages. Due to their unique properties, multivalent, intrinsically disordered proteins make ideal candidates to accomplish these vital tasks. A single protein with multiple binding sites may bind numerous partners,...
Resource Type:: Dissertation

ScholarsArchive@OSU

Towards Resolving Functional and Evolutionary Mysteries of the Large and Heterozygous Genome of Hop (Humulus lupulus) and the Cannabaceae Family Using Genomic Data Science

Underlying Mechanisms of the Anti-inflammatory and Antioxidant Effects of Quercetin in Human Aortic Endothelial Cells : Implications for Vascular Inflammation and Atherosclerosis

Conformational Consequences: Calcium Regulates the Association Between Dysferlin C2A & PI(4,5)P2

Initiation of Genome Instability and Preneoplastic Processes through Loss of Fhit Expression

Protein Disorder in the Evolution of Dynein Regulation

Interactions of yeast dynein with dynein light chain and dynactin: General implications for intrinsically disordered duplex scaffolds in multi-protein assemblies

Understanding Circadian and Light-activated Transcriptional Regulatory Changes During Aging in Drosophila melanogaster

Assembly and Regulation of WW-PPXY Complexes in Hippo Signaling

Characterization of the Structure and Dynamics of the Intrinsically Disordered Dynein Intermediate Chain and its Interactions with Regulatory Binding Partners

Strength in Numbers: How Multivalent WW-PPXY Interactions Regulate Cell Signaling

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