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Filtering by: Creator Dibble, Kimberly L. Academic Affiliation Biological and Population Health Sciences License Attribution 4.0 (CC BY 4.0)

Effect of digestion on stability of palivizumab IgG1 in the infant gastrointestinal tract

Creator:

Lueangsakulthai, Jiraporn, Kim, Bum Jin, Demers-Mathieu, Veronique, Sah, Baidya Nath P., Woo, Yeonhee, Olyaei, Amy, Aloia, Molly, O'Connor, Ann, Scottoline, Brian P., and Dallas, David C.

Abstract:

Background Potentially, orally administered antibodies specific to enteric pathogens could be administered to infants to prevent diarrheal infections, particularly in developing countries where diarrhea is a major problem. However, to prevent infection, such antibodies would need to resist degradation within the gastrointestinal tract. Methods Palivizumab, a recombinant antibody specific to...

Resource Type:

Article

Full Text:

microliters of commercial PEG-28 (100 ng/μL, Sigma Aldrich, St. Louis, MO, USA) were prepared as a stock