Background: Clostridium difficile is the main cause of nosocomial infections including antibiotic associated diarrhea, pseudomembranous colitis and toxic megacolon. During the course of Clostridium difficile infections (CDI), C. difficile undergoes sporulation and releases spores to the colonic environment. The elevated relapse rates of CDI suggest that C. difficile spores has...
Clostridium difficile is an important nosocomial pathogen that has become a major cause of antibiotic-associated diarrhea.
There is a general consensus that C. difficile spores play an important role in C. difficile pathogenesis, contributing to infection,
persistence, and transmission. Evidence has demonstrated that C. difficile spores have an outermost layer,...