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Filtering by: Creator Sokurenko, Evgeni V. Academic Affiliation Biomedical Sciences

Footprint of Positive Selection in Treponema pallidum subsp. pallidum Genome Sequences Suggests Adaptive Microevolution of the Syphilis Pathogen

Creator:

Giacani, Lorenzo, Chattopadhyay, Sujay, Centurion-Lara, Arturo, Jeffrey, BrendanM., Le, Hoavan T., Molini, Barbara J., Lukehart, Sheila A., Sokurenko, Evgeni V., and Rockey, Daniel D.

Abstract:

In the rabbit model of syphilis, infection phenotypes associated with the Nichols and Chicago strains of Treponema pallidum (T. pallidum), though similar, are not identical. Between these strains, significant differences are found in expression of, and antibody responses to some candidate virulence factors, suggesting the existence of functional genetic differences...

Resource Type:

Article

Full Text:

. Molini1, Sheila A. Lukehart1,4, Evgeni V. Sokurenko2, Daniel D. Rockey3 1 Department of Medicine