Search Constraints

Start Over
Filtering by: Subject Adsorption Remove constraint Subject: Adsorption Academic Affiliation Chemical, Biological and Environmental Engineering Remove constraint Academic Affiliation: Chemical, Biological and Environmental Engineering Advisor Mcguire, Joseph Remove constraint Advisor: Mcguire, Joseph

Search Results

  • Retention of protein repulsive character and antimicrobial activity of PEO brush layers following nisin entrapment

    Creator:
    Auxier, Julie A.
    Abstract:
    Nisin, an amphiphilic, antimicrobial peptide, has been shown to integrate into the hydrophobic inner region of poly(ethylene oxide) (PEO) brush layers; however, the presence of integrated nisin may compromise the protein repulsive character of the PEO layer. In particular, the introduction of fibrinogen to nisin-loaded brush layers has been observed...
    Resource Type:
    Masters Thesis
    Full Text:
    surrounding the possibility of fibrinogen adsorption warrant further investigation, as the location of

  • Molecular origins of peptide entrapment in polyethylene oxide layers

    Creator:
    Wu, Xiangming
    Abstract:
    A more quantitative understanding of peptide entrapment and elution from otherwise protein-repellent polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. Here we describe criteria for peptide integration and structural change within the PEO brush, and discuss the reversibility of peptide...
    Resource Type:
    Dissertation
    Full Text:
    used to record the adsorption and conformational changes of (amphiphilic) WLBU2 and S-WLBU2, and

  • The adsorption of human recombinant factor VIII in the presence of the nonionic triblock surfactant Pluronic® F-68 at the air-water interface

    Creator:
    Alkhatib, Aveen K.
    Abstract:
    The adsorption behavior of a human recombinant Factor VIII (rFVIII) in the presence of the nonionic, poly(ethylene oxide)-poly(propylene oxide)-poly(ethylene oxide) (PEO-PPO-PEO) triblock surfactant Pluronic® F-68 was evaluated by dynamic air-water tensiometry. Surface tension kinetics were recorded for F-68 in the absence of protein at concentrations ranging from 0 to 10,000...
    Resource Type:
    Masters Thesis
    Full Text:
    presented on December 9, 2009. Title: The Adsorption of Human Recombinant Factor VIII in the Presence of

  • Synthesis and evaluation of PEO-coated materials for microchannel-based hemodialysis

    Creator:
    Heintz, Keely
    Abstract:
    The marked increase in surface-to-volume ratio associated with microscale devices for hemodialysis leads to problems with hemocompatibility and blood flow distribution that are more challenging to manage than those encountered at the conventional scale. In this work, stable surface modifications with pendant polyethylene oxide (PEO) chains were produced on polycarbonate...
    Resource Type:
    Masters Thesis
    Full Text:
    microchannel and membrane materials. Protein adsorption was detected by measurement of surface-bound enzyme

  • Quantifying nisin adsorption behavior at pendant polyethylene oxide brush layers

    Creator:
    Dill, Justen K.
    Abstract:
    A more quantitative understanding of peptide loading and release from polyethylene oxide (PEO) brush layers will provide direction for development of new strategies for drug storage and delivery. The antimicrobial peptide nisin shows potent activity against Gram-positive bacteria including the most prevalent implant-associated pathogens, its mechanism of action minimizes the...
    Resource Type:
    Masters Thesis
    Full Text:
    : Quantifying Nisin Adsorption Behavior at Pendant Polyethylene Oxide Brush Layers Abstract approved

  • Nisin adsorption to PEO-PPO-PEO tri-block copolymer layers and its resistance to elution by fibrinogen

    Creator:
    Ryder, Matthew P.
    Abstract:
    While hydrophobic surfaces coated with the poly[ethylene oxide]-poly[propylene oxide]-poly[ethylene oxide] (PEO-PPO-PEO) surfactant Pluronic® F108 are highly resistant to plasma protein adsorption, the antimicrobial peptide nisin has been observed to adsorb in multilayer quantities at such surfaces, and the PEO chains themselves suggested to inhibit nisin exchange by blood proteins. But...
    Resource Type:
    Masters Thesis
    Full Text:
    degree of Master of Science in Chemical Engineering presented on May 18, 2009. Title: Nisin Adsorption

  • Molecular origins of surfactant-mediated stabilization of protein

    Creator:
    Lee, Hyo Jin
    Abstract:
    Nonionic surfactants are commonly used to stabilize proteins during upstream and downstream processing and drug formulation. Surfactants stabilize the proteins through two major mechanisms: (i) their preferential location at nearby interfaces, in this way precluding protein adsorption; and/or (ii) their association with protein into "complexes" that prevent proteins from interacting...
    Resource Type:
    Dissertation
    Full Text:
    : (i) their preferential location at nearby interfaces, in this way precluding protein adsorption