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Filtering by: Creator Parra, Gabriel I. Academic Affiliation Chemistry Advisor White, James D.

Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

Creator:

Choi, Younggi

Abstract:

PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...

Resource Type:

Dissertation

Full Text:

INDOLE ALKALOIDS: PART I. ASYMMETRIC SYNTHESIS OF (-)-IBOGAMINE. PART II. AN APPROACH TOWARD THE
Studies toward the total synthesis of phorboxazole A

Creator:

Kuntiyong, Punlop

Abstract:

Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...

Resource Type:

Dissertation

Full Text:

Dean of the Graduate School I understand that my dissertation will become part of the permanent
Phenolic oxidative coupling : an approach to the synthesis of pretazettine

Creator:

Chong, Wesley Kwan Mung

Abstract:

Various hypervalent iodine compounds were evaluated as reagents for intramolecular phenolic oxidative coupling. It was found that phenyliodine(III) bis(trifluoroacetate) was effective for the coupling of the monophenolic substrate 13a to 14a under neutral conditions. Vanadium oxytrifluoride and hypervalent iodine compounds were compared as oxidants for the conversion of 32 to...

Resource Type:

Dissertation

Full Text:

. ACKNOWLEDGEMENTS I would like to thank Dr. James D. White, who always provided direction and unfailing enthusiasm