Search Constraints

Start Over
Filtering by: Alternative title ssim Report no. 1678 Remove constraint Alternative title ssim: Report no. 1678 Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry Advisor White, James D. Remove constraint Advisor: White, James D.

Search Results

  • Approaches to the synthesis of trichothecenes

    Creator:
    Kim, No-soo
    Resource Type:
    Dissertation
    Full Text:
    Abstract of the Thesis of No-Soo Kim for the degree of Doctor of Philosophy in Chemistry presented on

  • Synthetic studies of nonadrides

    Creator:
    Drapela, Nicholas Ernest
    Abstract:
    An asymmetric approach to the synthesis of byssochlamic acid (1) is described. Regioisomeric enzymatic differentiation is described in the selective hydrolysis of dimethyl ester 30 by porcine liver esterase. Chiral dimethyl ester 42 was prepared by desymmetrization of cyclopentene 34 using porcine liver esterase. A key intramolecular [2+2]cycloaddition-cycloreversion photometathesis of...
    Resource Type:
    Dissertation
    Full Text:
    ) were carried out, but no desired product was isolated under these conditions. Redacted for Privacy

  • Synthetic studies on alkaloids : part I, an approach toward the synthesis of (̳+)-koumine : part II, an approach toward the synthesis of (̳+)-morphine

    Creator:
    Stappenbeck, Frank
    Resource Type:
    Dissertation
    Full Text:
    reputation in Chinese forensic medicine for its implication in homicides. The first report available in the

  • The total synthesis of (-)- acorenone B ; Approaches to the synthesis of mycosporin (P 310)

    Creator:
    Ruppert, John Fredrick
    Resource Type:
    Dissertation
    Full Text:
    stereoisomers. No attempt was made to separate these isomers. An Efficient Synthesis of Homoallylic Alcohols

  • Alkylation studies on Hagemann's ester: an approach to the synthesis of the trisporic acids

    Creator:
    Sung, Wing Lam
    Abstract:
    Sequential alkylation of Hagemann's ester with methyl and methallyl halides has been studied. Treatment of Hagemann's ester with methyl iodide and sodium ethoxide gave a mixture of 21 and 25 in a ratio of 4:1. Alkylation of 21 with methallyl chloride and potassium t-butoxide afforded a mixture of 37 and...
    Resource Type:
    Masters Thesis
    Full Text:
    in this system. Apparently, no further alkylation of a disubstituted Hagemann's ester derivative

  • Total synthesis of (-)-7-epicylindrospermopsin

    Creator:
    Hansen, Joshua D.
    Abstract:
    The first asymmetric synthesis of (-)-7-epicylindrospermopsin via intramolecular nitrone cycloaddition is described. The synthesis utilized a convergent approach to prepare the cycloaddition precursor 176, which was assembled by condensation of hydroxylamine 175 with aldehyde 145. Hydroxylamine 175 was synthesized from ethylene glycol (166) in seven steps. Aldehyde 145 was completed...
    Resource Type:
    Dissertation
    Full Text:
    sunlight in an algal solution; however, no decomposition was recorded in pure cylindrospermopsin in Milli

  • Synthetic transformations of shikimic acid

    Creator:
    White, Edward D., III
    Abstract:
    Four strategies which involve synthetic elaboration of the shikimate nucleus are discussed. Methyl shikimate was differentially protected as the 3,4-0-cyclopentylidene ketal and as the 5- 0- tert- butyldiphenylsilyl ether. The methyl ester was then reduced with diisobutylaluminum hydride and the resulting allylic alcohol was oxidized to aldehyde 47 with pyridinium...
    Resource Type:
    Masters Thesis
    Full Text:
    acetonide of methyl shikimate with lithium aluminum hydride cleanly gave the primary alcohol 10 with no

  • Studies toward the total synthesis of (+)-providencin

    Creator:
    Jana, Somnath
    Abstract:
    Studies toward the total synthesis of (+)-providencin (1), a highly oxygenated cembranoid dipterpene with a unique bicyclo[12.2.0]hexadecane skeleton and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 320 and 332 which contain all of the carbon atoms of 1. In a first generation approach...
    Resource Type:
    Dissertation
    Full Text:
    to date there is no total synthesis of this natural product. 7 Intricarene (17) was synthesized

  • Phenolic oxidative coupling : an approach to the synthesis of pretazettine

    Creator:
    Chong, Wesley Kwan Mung
    Abstract:
    Various hypervalent iodine compounds were evaluated as reagents for intramolecular phenolic oxidative coupling. It was found that phenyliodine(III) bis(trifluoroacetate) was effective for the coupling of the monophenolic substrate 13a to 14a under neutral conditions. Vanadium oxytrifluoride and hypervalent iodine compounds were compared as oxidants for the conversion of 32 to...
    Resource Type:
    Dissertation
    Full Text:
    ; however, no effects have ever been observed with chroni- cally infected cells. In addition to taking

  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
    Full Text:
    required by FDA, drugs with toxic enantiomers like thalidomide no longer reach the consumer. On the other