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Filtering by: Creator Sorensen, Hilarie L. Academic Affiliation Chemistry Advisor White, James D.

Synthesis of epothilones and epothilone analogues

Creator:

Sundermann, Kurt F.

Abstract:

A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key reactions include an anti-Felkin aldol condensation to set the C6 and C7 stereochemistry, a directed α-hydroxylation to install the C15 (S)-hydroxyl substituent, and a Wittig condensation to...

Resource Type:

Dissertation

Full Text:

Epothilone B10 (11) NtS.OH Epothilone G1 (12), R = H Epothilorie G2 (13), R Me L/,SS0H Epothitone H1 (14
Cyclization of olefinic β-ketoesters. An approach to the synthesis of aplysistatin

Creator:

Skeean, Richard William

Resource Type:

Dissertation

Full Text:

acknowledge the Nicholas L. Tartar Foundation for its financial aid during a portion of this work. Finally