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Filtering by: Creator Parra, Gabriel I. Academic Affiliation Chemistry Committee Member Anderson, Kim

Stereoselective synthesis & application of enantioenriched main group α-haloalkyl organometal reagents

Creator:

Emerson, Christopher R.

Abstract:

Sulfoxide-ligand exchange (SLE) and asymmetric halogen-metal exchange (AHME) processes were separately examined for the enantioselective synthesis of functionalized alpha-haloalkylmetal (carbenoid) reagents. Carbenoids derived from SLE were used to effect stereospecific reagent-controlled homologation (StReCH) of boronic esters and those generated via AHME were engaged in Darzens-type chemistry with aldehydes. Abstract for...

Resource Type:

Dissertation

Full Text:

of: acid chloride formation [(COCl)2 and cat. DMF)], aminolysis (with R2NH, R = Me, Et, i-Pr; 65
A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:

Points, Gary L., III

Abstract:

Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...

Resource Type:

Dissertation

Full Text:

Chemistry Dean of the Graduate School I understand that my