Index Catalog // ScholarsArchive@OSU

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: Synthesis Abstract approved: ______________________________________________________ Paul Ha

Racemic and Enantioselective Synthesis of Cavicularin

Creator:: Zhao, Peng
Abstract:: This dissertation describes the racemic and enantioselective synthesis cavicularin. Cavicularin is a macrocyclic bisbibenzyls family member natural product. It has been an attractive synthetic target due to its intriguing structure: the macrocyclic core imparts sufficient strain on the system to force one benzene rings to adopt a boat-shaped conformation, out...
Resource Type:: Dissertation

Progress Towards the Total Synthesis of Bazzanin K

Creator:: Salvo, Patrick
Abstract:: Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
Resource Type:: Masters Thesis
Full Text:: . 5 B. S. Moore, J. L. Chen, G. M. L. Patterson, R. E. Moore, L. S. Brinen, Y. Kato, and J. Clardy, J

Improvements in synthesis and response techniques of ion-selective sensors

Creator:: Pylypiuk, Nataliia
Abstract:: Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...
Resource Type:: Masters Thesis
Full Text:: commitment of my graduate committee members: Kim Anderson, Paul Blakemore and Christopher Beaudry

Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

Creator:: Carlson, Erik
Abstract:: Effective methods for the enantiopure formation of substituted piperidine rings are significantly important due to their presence in alkaloid products. A valuable method to form these ring systems would be via an intramolecular heteroatom Michael addition from the corresponding enone or enal. Described herein is a methodolgy that has been...
Resource Type:: Masters Thesis
Full Text:: extend my appreciation to my committee members, Prof. Paul R. Blakemore, Prof. Kevin P. Gable, Prof

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: members, Professor Rich G. Carter, Professor Paul R. Blakemore, Professor Philip J. Proteau and

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: !committee,!Prof.!Paul!Blakemore,!Prof.!Paul!Cheong,!Prof.!Kerry!McPhaill! and!Prof.!Steve!Giovanini! for

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

Creator:: Points, Gary L., III
Abstract:: Aromatic heterocycles are core structural motifs in natural products, pharmaceuticals and biological polymers. Indoles, in particular, represent a significant subclass of aromatic heterocycles, both in terms of sheer numbers, but also in biological and pharmaceutical relevance. As such, new methodologies for the synthesis of indoles represent an important and continually...
Resource Type:: Dissertation
Full Text:: formation of a new carbon bond ortho to the R-substituent on the aryl ring is disfavored due to steric

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Creator:: Overacker, Ross D.
Abstract:: Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
Resource Type:: Dissertation
Full Text:: positivity, hard work, and determination are a model for all. I would like to thank Paul Blakemore for

Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

Creator:: Kaweesa, Elizabeth Namagoba
Abstract:: Mensacarcin is a stereogenic complex polyketide with potent anti-tumor activity produced by a soil-dwelling Streptomyces bottropensis. The US National Cancer Institute (NCI) 60 human tumor cell line anticancer drug screen (NCI-60) reveals mensacarcin’s cytostatic properties in almost all tested cell lines and distinct cytotoxic properties specifically in eight melanoma cell...
Resource Type:: Masters Thesis
Full Text:: support and guidance throughout my studies. I would like to thank my committee members: Dr. Paul

ScholarsArchive@OSU

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Racemic and Enantioselective Synthesis of Cavicularin

Progress Towards the Total Synthesis of Bazzanin K

Improvements in synthesis and response techniques of ion-selective sensors

Development of organocatalyzed, intramolecular heteroatom Michael addition and application towards alkaloid synthesis

Studies towards the total syntheses of (+)-phomactins A, D and G

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

A Pyrone Diels–Alder Approach to Substituted Indoles and Carbazoles and the Synthesis of New Ropinirole Analogues

New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

Insights into Cytostatic and Cytotoxic Properties of the Natural Product Mensacarcin

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