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Filtering by: Creator Cardinal, Bradley J. Remove constraint Creator: Cardinal, Bradley J. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry Committee Member Blakemore, Paul Remove constraint Committee Member: Blakemore, Paul

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  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation
    Full Text:
    B, as a sex attractant.5,6,7,8 Male Cardinal birds (Cardinalis cardinalis) use the red pigment

  • Rationalization and innovative design of asymmetric organocatalysts through computational investigation

    Creator:
    Johnston, Ryne Connell
    Abstract:
    My work on computing complex catalyzed organic transformations reveals that only a few subtle chemical factors, e.g. non-classical hydrogen bonding, (hyper)conjugation and steric effects, common across different catalyst manifolds are critical for catalysis and selectivity. Rational manipulation and exploitation of these factors has led to improved catalyst designs, which has...
    Resource Type:
    Dissertation
    Full Text:
    .; Brizzolara, A.; Landesman, H.; Szmuszkovicz, J.; Terrell, R. J. Am. Chem. Soc. 1963, 85, 207; (b) Stork, G