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Progress Towards the Total Synthesis of Bazzanin K

Creator:: Salvo, Patrick
Abstract:: Molecular chirality plays a critical role in chemistry, biology, and medicine. To study and better understand conformational chirality, it is necessary to obtain structurally interesting molecules that exhibit this form of chirality. Our lab utilizes total synthesis and methodological development to obtain conformationally chiral natural products of interest. We believe...
Resource Type:: Masters Thesis
Full Text:: Thesis_Bazzanin K_Salvage AN ABSTRACT OF THE THESIS

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Creator:: Salih, M. Quamar
Abstract:: Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
Resource Type:: Dissertation
Full Text:: !M.!Beaudry! ! ! Abstract! ! ! Since!the!discovery!of!molecular!chirality! in!1848,!this!notion!has

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:: Ferreira, Andrew
Abstract:: The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
Resource Type:: Dissertation
Full Text:: configuration was determined for each of the alkaloids using circular dichroism (CD) spectroscopy and the

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: Page 1.1. Molecular structure and crystal structure of (+)-phomactin A (1

Improvements in synthesis and response techniques of ion-selective sensors

Creator:: Pylypiuk, Nataliia
Abstract:: Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...
Resource Type:: Masters Thesis
Full Text:: AN ABSTRACT OF THE THESIS OF Nataliia Pylypiuk for the degree of

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Creator:: Juniku, Rajan B.
Abstract:: Part I: Racemic and asymmetric syntheses of a new substance with prospective antidepressant properties were achieved. In vitro assays with synthetic racemates (±)-25 and (±)-26 suggested that the former is a relatively selective inhibitor of serotonin transporter whereas the latter is a more balanced inhibitor of both serotonin and norepinephrine...
Resource Type:: Dissertation
Full Text:: Microsoft Word - Pretext AN ABSTRACT OF THE DISSERTATION OF

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Creator:: Snyder, Kevin M.
Abstract:: In this report, three studies are presented that aid in the development of drug discovery and their synthesis. In each, the importance of the marriage between computations and experiments is highlighted. Continued efforts in this vein are essential for future efforts towards improving human health. The first case study investigated...
Resource Type:: Masters Thesis
Full Text:: molecular dynamics (MD),[14,15] which has the advantage of directly modeling the impact of solvent on the

Studies toward the total synthesis of sanglifehrin A

Creator:: Suttisintong, Khomson
Abstract:: Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
Resource Type:: Dissertation
Full Text:: B, respectively, during isolation in the presence of methanol. The molecular formulas of the

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

Creator:: Johnston, Ryne Connell
Abstract:: My work on computing complex catalyzed organic transformations reveals that only a few subtle chemical factors, e.g. non-classical hydrogen bonding, (hyper)conjugation and steric effects, common across different catalyst manifolds are critical for catalysis and selectivity. Rational manipulation and exploitation of these factors has led to improved catalyst designs, which has...
Resource Type:: Dissertation
Full Text:: routine begins with a mid-level, gas phase geometry optimization of molecular mechanics geometries with

Studies toward the total synthesis of azaspiracid-1

Creator:: Kuiper, Damien L.
Abstract:: Azaspiracid has generated an enormous amount of scientific interest in the fourteen years since its initial discovery. The structure contains a 6,5,6 bis-spiroketal, a [3.3.1] bicyclic ketal and a 6,5-spiroaminal linkage as key moieties. With 9 rings, 20 stereocenters and three alkenes, the azaspiracid immediately attracted the interest of the...
Resource Type:: Dissertation
Full Text:: homogenates 3 of P. crassipes by mass spectroscopy, repeated attempts to induce azaspiracid

ScholarsArchive@OSU

Progress Towards the Total Synthesis of Bazzanin K

Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Studies towards the total syntheses of (+)-phomactins A, D and G

Improvements in synthesis and response techniques of ion-selective sensors

Part I: Synthesis and evaluation of synosutine as an inhibitor of serotonin, norepinephrine, and dopamine transporters Part II: Asymmetric approach to the tetracyclic core of neomangicol A

Towards the Perfect Marriage Between Theory and Experiments in Drug Discovery and Synthesis : Insights into Structure Determination of Complex Natural Products and Mechanistic Understandings of Lactam Synthesis

Studies toward the total synthesis of sanglifehrin A

Rationalization and innovative design of asymmetric organocatalysts through computational investigation

Studies toward the total synthesis of azaspiracid-1

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