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Filtering by: Creator Quinn, Thomas P. Remove constraint Creator: Quinn, Thomas P. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry Committee Member Blakemore, Paul Remove constraint Committee Member: Blakemore, Paul

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  • Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

    Creator:
    Tonsiengsom, Sorasaree
    Abstract:
    Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
    Resource Type:
    Dissertation
    Full Text:
    , SALACIN AND ALMAZOLES Abstract approved: Kevin P. Gable Studies

  • Studies towards the total syntheses of (+)-phomactins A, D and G

    Creator:
    Schwartz, Keith D.
    Abstract:
    Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
    Resource Type:
    Dissertation
    Full Text:
    Jones, Professor Kevin P. Gable Dr. Hua Yang Mary Mucia Professor Max Deinzer Dr.Miroslav Terinek Dr

  • Improvements in synthesis and response techniques of ion-selective sensors

    Creator:
    Pylypiuk, Nataliia
    Abstract:
    Two improvements to the established procedures for synthesis and response detection of ion-selective optical sensors (optodes) were introduced. The first improvement addresses the drawback of organic dye (optode-localized chromoionophore) photobleaching. This positively impacts fluorescence response and allows for (1) direct measurement of hydrogen ion activity upon binding with the dye,...
    Resource Type:
    Masters Thesis
    Full Text:
    . Chem. 2 (2009): 57-76 [4] Moody, G., R. Oke, and J. Thomas. "A calcium-sensitive electrode based

  • Studies toward the total synthesis of sanglifehrin A

    Creator:
    Suttisintong, Khomson
    Abstract:
    Studies toward synthesis of subunits of sanglifehrin A, an immunosuppressant featuring a highly substituted [5,5]-spirolactam moiety as well as a 22-membered macrocycle are described. The macrolactone contains a peptidic backbone characterized by an unusual [beta]-substituted (S)-piperazic acid and (S)-m-hydroxyphenylalanine units. These studies resulted in the synthesis of advanced intermediate 358...
    Resource Type:
    Dissertation
    Full Text:
    committee members, Professor Rich G. Carter, Professor Paul R. Blakemore, Professor Kevin P. Gable and

  • Conformationally chiral diphenylethers and the enantioselective Ullmann etherification

    Creator:
    Salih, M. Quamar
    Abstract:
    Since the discovery of molecular chirality in 1848, this notion has had a substantial impact on medicine, biology, and chemistry. Extensive effort has been directed towards the construction of chiral molecules that contain sp³ hybridized stereogenic centers. In contrast, less effort has been dedicated to molecules that are chiral by...
    Resource Type:
    Dissertation
    Full Text:
    =ray!structure!of! its! p=bromobenzoate! congener.! It! was! determined! to! have! pR! absolute

  • Rationalization and innovative design of asymmetric organocatalysts through computational investigation

    Creator:
    Johnston, Ryne Connell
    Abstract:
    My work on computing complex catalyzed organic transformations reveals that only a few subtle chemical factors, e.g. non-classical hydrogen bonding, (hyper)conjugation and steric effects, common across different catalyst manifolds are critical for catalysis and selectivity. Rational manipulation and exploitation of these factors has led to improved catalyst designs, which has...
    Resource Type:
    Dissertation
    Full Text:
    .; Hausmann, H.; Guenther, S.; Schreiner, P. R. Eur. J. Org. Chem. 2012, 2012, 5919 [38] Thomas, J. M

  • Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

    Creator:
    Ferreira, Andrew
    Abstract:
    The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
    Resource Type:
    Dissertation
    Full Text:
    ) Norton, R. S.; Wells, R. J. J. Am. Chem. Soc. 1982, 104, 3628–3635. (d) Thayumanavan, S.; Beak, P

  • Pactamycin Inspired Drug Discovery: A Synthetic and Chemoenzymatic Approach

    Creator:
    Brumsted, Corey J.
    Abstract:
    Pactamycin, first reported in 1962, is a potent antitumor antibiotic produced by the soil bacterium Streptomyces pactum. Structurally, it contains a cyclopentitol core unit, a 3-aminoacetophenone (3AAP), a 6-methylsalicylic acid (6-MSA), and a N,N-dimethyl urea. The aminocyclopentitol ring is derived from glucose, possibly via N-acetyl glucosamine (GlcNAc), the 3-aminoacetophenone (3AAP)...
    Resource Type:
    Dissertation
    Full Text:
    analogs against P. aeruginosa (A) and S. aureus (B). PCT = pactamycin; Amp = ampicillin; Apra = apramycin

  • Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

    Creator:
    Adpressa, Donovon A.
    Abstract:
    Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
    Resource Type:
    Dissertation
    Full Text:
    , C.-Y.; Xu, Y. Mar. Drugs 2017, 15, 266. 6. Qian, P. Y.; Xu, Y.; Fusetani, N. Biofouling 2010, 26

  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    .; Herrmann, A.; Strother, J. A.; Brack-Werner, R.; Blakemore, P. R.; Loesgen, S. Biorg. Med. Chem. 2019, 27