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Filtering by: Creator Mafimisebi, T. E. Remove constraint Creator: Mafimisebi, T. E. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry Committee Member Blakemore, Paul R. Remove constraint Committee Member: Blakemore, Paul R.

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  • Total Synthesis of Aspidosperma Alkaloids Leuconoxine, Melodinine E and Mersicarpine and Synthetic Studies directed toward the Iboga Alkaloid Ibogaine: Progress directed toward the dimeric Cephalotaxus Alkaloid Cephalancetine C

    Creator:
    Kim, GilSoo
    Abstract:
    The first part of this manuscript is about the total synthesis of the aspidosperma alkaloids leuconoxine, melodinine E and mersicarpine. Our synthetic strategy used a radical translocation-conjugate addition cascade to construct the core of the natural product. Specifically, a vinyl radical was generated from the homolysis of the C–I bond...
    Resource Type:
    Dissertation
    Full Text:
    . E. Kuehne, J. Raucci, T. E. Wilson, D. Larson, R. W. Keller Jr., J. N. Carlson, Brain Res. 1994

  • Polymeric submicron optical ion-selective sensors

    Creator:
    Bychkova, Valeriya
    Abstract:
    Ion-selective polymeric optical sensors – ion optodes – are a promising alternative to ion-selective electrodes and fluorescent dyes for analytical and biological applications, e.g. extra- and intracellular measurements. They are non-toxic, highly selective robust probes for ionic fluxes monitoring. A large-scale fabrication of ion optodes using a solvent displacement method...
    Resource Type:
    Dissertation
    Full Text:
    Appendix E. Photoresponsive ion-selective optical sensors: equilibrium and non-equilibrium response

  • Expanding the scope of a Diels-Alder approach to biaryl synthesis

    Creator:
    Schwartz, Johanna Perkins
    Abstract:
    A Diels-Alder approach to biaryls (DAB) has been applied towards the synthesis of highly substituted, programmable biaryl templates. Tri- and tetra-ortho-substituted biaryls can be produced in just three to four steps from commercially available materials utilizing the Diels-Alder [4+2] cycloaddition. The methods described herein will illustrate the ability of mono...
    Resource Type:
    Dissertation
    Full Text:
    . Eur. J. 2004, 10, 61. (e) Nishida, J.; Suzuki, T.; Ohkita, M; Tsuji, T. Angew. Chem

  • The development of aminal radicals for the synthesis of nitrogen-rich natural products

    Creator:
    Schiedler, David A.
    Abstract:
    Organic compounds which contain one or more nitrogen atoms are especially important as they are disproportionately represented among biologically active molecules. As a result, significant effort has been focused on the development of methods for the synthesis of nitrogenous molecules. We identified the aminal as an under-explored functional group. Despite...
    Resource Type:
    Dissertation
    Full Text:
    . 1995, 60, 5935–5945. (c) Sabanov, V. K.; Kibizova, A. Y.; Klimov, E. S.; Berberova, N. T

  • Studies towards the total synthesis of (-)-kendomycin

    Creator:
    Smits, Helmars
    Abstract:
    Studies towards the total synthesis of (−)-kendomycin (1), a bacterial metabolite with a unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediate 208, containing all of the carbon atoms of 1. A Dötz annulation between alkyne 122 and novel chromium carbenoid...
    Resource Type:
    Dissertation
    Full Text:
    aqueous hydrogen fluoride produced kendomycin 1. OMe TBSO O I O HO O I t-BuLi, Et2O, THF; 9-BBN

  • Synthetic Studies towards Highly Oxygenated Furanyl Diterpenoids

    Creator:
    Goswami, Subir
    Abstract:
    The furanyl diterpenoid family of natural products has drawn the attention of both synthetic organic chemists and pharmacologists due to their complex structural architectures and diverse biological activity. Among them, wortmannin has been most extensively studied for biological activities. All these furanyl diterpenoids consist of a highly strained naptha[1,8-bc]furan core,...
    Resource Type:
    Dissertation
    Full Text:
    , O.; Stephens, L.; Hawkins, P. T.; Wymann, M. P.; Williams, R. L. Mol. Cell 2000, 6, 909-919. (e

  • Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

    Creator:
    Li, Xin
    Abstract:
    This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
    Resource Type:
    Dissertation
    Full Text:
    of multiple abietane diterpenoids (ent-triptobenzene T, vitexifolin C, hinokiol, 4-epi

  • Computational Investigation and Prediction of Mechanisms and Stereocontrol in Complex Organic Reactions

    Creator:
    Pattawong, Ommidala
    Abstract:
    Complex organic transformations, such as the addition of pyrrole to ketene using planar chiral organocatalyst (*PPY), the four-component anhydride- Manniach reactions, and the site-selective desymmetrization of meso-1,2-diol, are remarkable synthetic reactions that provide high yield and high selectivity. However, the exact mechanism and origins of stereocontrol for theses synthetic organic...
    Resource Type:
    Dissertation
    Full Text:
    . Rev. 2006, 106, 17. (14) Biggs-Houck, J. E.; Younai, A.; Shaw, J. T. Curr. Opin. Chem. Biol. 2010

  • Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

    Creator:
    Shaw, Subrata
    Abstract:
    This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
    Resource Type:
    Dissertation
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    , P.; Breith, E.; Liibbe, E.; Tsumaki, T. Justus Liebigs Ann. Chem. 1933, 503, 84. (b) Diehl, H

  • A Diels-Alder approach to biaryl synthesis

    Creator:
    Ashburn, Bradley O.
    Abstract:
    An expedient approach to the synthesis of a wide range of highly programmable biaryl templates has been accomplished. Utilizing the Diels-Alder [4+2] cycloaddition, a wide range of tri- and tetra-ortho-substituted biaryls have been synthesized in only three to four steps from commercially available materials. We have successfully synthesized entire classes...
    Resource Type:
    Dissertation
    Full Text:
    , T. E.; Walker, S. D.; Martinelli, J. R.; Buchwald, S. L. J. Am. Chem. Soc. 15