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Filtering by: Creator Palo, D. Remove constraint Creator: Palo, D. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry Committee Member Deinzer, Max Remove constraint Committee Member: Deinzer, Max

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  • Synthesis of furanoeremophilane sesquiterpenoids

    Creator:
    Shanmugham, Meenakshi Sundaram
    Abstract:
    Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
    Resource Type:
    Dissertation
    Full Text:
    FURANOEREMOPHILANE SESQUITERPENOIDS Abstract approved: James D. White Two approaches to the tricyclic core of the

  • Mass spectrometric analysis of UV-crosslinked protein-nucleic acid complexes

    Creator:
    Doneanu, Catalin E.
    Abstract:
    The DNA-binding domains of E. coli uracil-DNA glycosylase (Ung) and human replication protein A (hRPA) were studied using a general protocol developed in our laboratory for probing protein-DNA interactions. The procedure involves purification and mass spectrometric analysis of the nucleopeptide-products of a tryptically digested UV-crosslinked protein-nucleic acid complex. In the...
    Resource Type:
    Dissertation
    Full Text:
    stable electrospray depends on the distance from the liquid jet to the counter-electrode (d), the