Index Catalog // ScholarsArchive@OSU

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Creator:: Neuhaus, George F.
Abstract:: The study of natural products (NPs) and their application has shaped humanity. Starting with the idea of using plants as medicine, it has now grown into the science of purifying and identifying organic molecules from nature to study their inherent biological activities. Understanding the molecular structures of NPs is the...
Resource Type:: Dissertation
Full Text:: Rokas. Dr. Mi-Kyung Lee and Dr. Hee-Soo Park performed the genome-wide analyses of genetic mutants

Expediting the Generation and Analysis of Amorphous Oxide Computational Models: Modeling Complex Systems Swiftly

Creator:: Buchanan, Jacob C.
Abstract:: In this dissertation, the process of computational modeling of amorphous oxide materials is studied. Amorphous oxides have random atomic arrangements with no long-range structural order which makes it difficult to study structure-property relationships. Despite the difficulties, amorphous oxides have great uses as semiconductors and dielectrics in thin-film transistors. The ability...
Resource Type:: Dissertation
Full Text:: Page Figure 2.1 In-O bond length distributions for 5, 10, and 243 formula unit cells sampled over

Unique Structural Properties and Motifs of Metal-Oxides from Solids to Clusters

Creator:: Malmberg, Christopher E.
Abstract:: In this dissertation, the structural properties, thermodynamics and defect behavior of amorphous metal oxides and polyoxometalates are studied. Amorphous metal oxides have many applications, most notably as a semiconducting material used as the active matrix of thin film transistors. Alas, the amorphous nature of these materials makes studying them rather...
Resource Type:: Dissertation
Full Text:: Chapter 2. Ultrabroadband Density of States of Amorphous In-Ga-Zn-O .................. 7 2.1 Abstract

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Creator:: Melbardis, John
Abstract:: In previous work (Blakemore et al. Org. Lett. 2005, 7, 4721; Heterocycles 2006, 70, 609), successful elaborations of the lupine alkaloids (±)-α-isosparteine (dl-2) and (±)-β-isosparteine (dl-3) were realized from a common tetraoxobispidine precursor, 3,7-diallyl -2,4,6,8-tetraoxo-3,7-diazabicyclo[3.3.1]nonane (93). Herein, the tetraoxobispidine approach to lupine alkaloids was extended to a total synthesis of...
Resource Type:: Masters Thesis
Full Text:: 3 NHN cytisine (7) NN sparteine (1) O H H N lupinine (6) H OH N N O H H

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Creator:: Shaw, Subrata
Abstract:: This thesis describes the development of a new enantioselective synthetic method employing chiral cis-2,5-diaminobicyclo[2.2.2]octane-based organometallic catalysts. The significance of this new method to organic synthesis is illustrated with preparation of enantioenriched products that are transformed to important pharmaceutical agents. Chapter 1 provides a brief historical overview of asymmetric catalysis, especially...
Resource Type:: Dissertation
Full Text:: enzyme present in vivo, converts the (R) e n anti o me r of 6 to the active (S)-enantiomer.4 / NH 0 0

Tracking Photoinduced Primary Events with Femtosecond Stimulated Raman Spectroscopy and Calculations

Creator:: Wang, Yanli
Abstract:: Femtosecond stimulated Raman spectroscopy (FSRS) is a powerful ultrafast technique which can track photoinduced excited state structural events on femtosecond (fs) to picosecond (ps) timescales. In addition to high temporal and spectral resolutions, FSRS provides a broad spectral window from ca. 100—2000 cm-1 for detection, enabling the direct mapping of...
Resource Type:: Dissertation
Full Text:: ). ......................................................................... 237 Figure 5.4. Distribution of the O···O distance between the chromophore phenolic hydroxyl and

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Creator:: Almlie, C. Kyle
Abstract:: Fluorescence has proven to be a robust and powerful method of analysis in numerous fields: forensics, pharmaceutics, geology, food science, and environmental sciences have all developed a large collection of fluorescence instruments and methods to overcome application-specific challenges. Biological applications saw the same development of a fluorescence toolkit with methods...
Resource Type:: Dissertation

Zero Kinetic Energy Photoelectron Spectroscopy of Polycyclic Aromatic Hydrocarbons

Creator:: Harthcock, Colin
Abstract:: In this dissertation, I describe spectroscopic studies of jet-cooled polycyclic aromatic hydrocarbons (PAH) and one nitrogen substituted PAH (PANH) using pulsed field zero kinetic energy (ZEKE) photoelectron spectroscopy and resonantly enhanced multiphoton ionization (REMPI) spectroscopy. Recently, there has been a demand for far-infrared (FIR) spectral information of astrophysically relevant molecules...
Resource Type:: Dissertation
Full Text:: , O.; Oomens, J. Gas-phase infrared spectra of cationized nitrogen-substituted polycyclic aromatic

Per- and Polyfluoroalkyl Substances (PFAS) in Environmental Air-Water Matrices and Light Non-Aqueous Phase Liquids (LNAPL)

Creator:: Schwichtenberg, Trever J.
Abstract:: The presence of per- and polyfluoroalkyl substances (PFAS), organic contaminants first synthesized in the 1940s, has been reported worldwide in a variety of environmental matrices and ultimately in biological systems including humans. Ongoing research into PFAS has included identifying novel PFAS, assessing their fate and transport in the environment, and...
Resource Type:: Dissertation
Full Text:: methylene, 2. aliphatic methyl and methylene near O and N, 3. O-alkyl, 4. H-alpha protons from protein, 5

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation

ScholarsArchive@OSU

Gene Expression, Structure Elucidation, and Bioactivity of Aspergillus Natural Products

Expediting the Generation and Analysis of Amorphous Oxide Computational Models: Modeling Complex Systems Swiftly

Unique Structural Properties and Motifs of Metal-Oxides from Solids to Clusters

Total synthesis of sparteine alkaloids from a common tetraoxobispidine intermediate

Cis-2,5-diaminobicyclo[2.2.2]octane : a novel C₂-symmetric scaffold for asymmetric catalysis

Tracking Photoinduced Primary Events with Femtosecond Stimulated Raman Spectroscopy and Calculations

CoLocalized Excitation Emission Resolution : A CLEER approach for multicolor fluorescence analysis

Zero Kinetic Energy Photoelectron Spectroscopy of Polycyclic Aromatic Hydrocarbons

Per- and Polyfluoroalkyl Substances (PFAS) in Environmental Air-Water Matrices and Light Non-Aqueous Phase Liquids (LNAPL)

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

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