Index Catalog // ScholarsArchive@OSU

Start Over

Filtering by: Creator Slegers, Nathan J. Academic Affiliation Chemistry Creator Allen, Scott E.

Active site studies and design of ligands for affinity column separation of 2,5-dihydroxyacetanilide epoxidase (DHAE) I and II

Creator:

Allen, Scott E.

Abstract:

A series of compounds, 7-8 and 20-25, were tested as competitive inhibitors of 2,5-dihydroxyacetanilide epoxidase I (DHAE I) and DHAE II. A Hammett plot was constructed for each enzyme to determine the effect of electron density on inhibition. DHAE I gave a linear, highly correlated plot (r²=0.91) that signifies the...

Resource Type:

Dissertation

Full Text:

inhibitors of CEase varied fragment enzyme AG0 (kJ/mol) MGf (J/mol*A3) N-alkyl chain rat CEase 14 ± 2