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Filtering by: Creator Parra, Gabriel I. Academic Affiliation Chemistry Decade 2000-2009

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:

Tonsiengsom, Sorasaree

Abstract:

Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...

Resource Type:

Dissertation

Full Text:

and Gabriel-Robinson oxazole synthesis with chiral, nonracemic keto amides. An integral aspect of
Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

Creator:

Choi, Younggi

Abstract:

PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...

Resource Type:

Dissertation

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INDOLE ALKALOIDS: PART I. ASYMMETRIC SYNTHESIS OF (-)-IBOGAMINE. PART II. AN APPROACH TOWARD THE
Studies toward the total synthesis of phorboxazole A

Creator:

Kuntiyong, Punlop

Abstract:

Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...

Resource Type:

Dissertation

Full Text:

Dean of the Graduate School I understand that my dissertation will become part of the permanent