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Filtering by: Creator Kass, David Academic Affiliation Chemistry Degree Level Doctoral

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:

Yang, Liping

Abstract:

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....

Resource Type:

Dissertation

Full Text:

like to further express my gratitude to Mr. David Broderick, who provided me with protein of high
From electrophoresis to dielectrophoresis: designing, fabricating, and evaluating an electroformed ratchet type microfluidic dielectrophoresis device

Creator:

Gonzalez, Carlos F.

Abstract:

Dielectrophoresis (DEP) is a separation method in which a non-uniform electric field is used to induce a dipole moment in a suspended particle. If the polarization of the particle is greater than that of the suspending medium, the particle will move towards the region of higher field strength (positive DEP);...

Resource Type:

Dissertation
Photoelectron spectroscopy of small molecules

Creator:

Bomben, Kenneth D.

Abstract:

The photoelectron spectra of a series of halogenated molecules have been investigated in the gas phase. Both core-ionization energies and Auger kinetic energies were measured to probe the nature of the interaction that holds a core electron to the molecule. It was found that satellite structure (shake) could be used...

Resource Type:

Dissertation