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Filtering by: Creator Palo, D. Remove constraint Creator: Palo, D. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry Degree Name Doctor of Philosophy (Ph.D.) Remove constraint Degree Name: Doctor of Philosophy (Ph.D.) License All rights reserved Remove constraint License: All rights reserved

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  • Studies toward the total synthesis of phorboxazole A

    Creator:
    Kuntiyong, Punlop
    Abstract:
    Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...
    Resource Type:
    Dissertation
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    TOTAL SYNTHESIS OF PHORBOXAZOLE A. Abstract approved: James D. White Studies toward the total

  • Synthesis of furanoeremophilane sesquiterpenoids

    Creator:
    Shanmugham, Meenakshi Sundaram
    Abstract:
    Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
    Resource Type:
    Dissertation
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    FURANOEREMOPHILANE SESQUITERPENOIDS Abstract approved: James D. White Two approaches to the tricyclic core of the

  • Total synthesis of phorboxazole A

    Creator:
    Lee, Tae Hee
    Abstract:
    The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
    Resource Type:
    Dissertation
    Full Text:
    : James D. White The total synthesis of a highly potent cytotoxic marine natural product

  • Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

    Creator:
    Choi, Younggi
    Abstract:
    PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
    Resource Type:
    Dissertation
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    SYNTHESIS OF KOUMINE. Abstracted approved: James D. White PART I. The preparation of ()-ibogamine (1) in

  • Semi-volatile organic compounds as molecular markers for atmospheric and ecosystem transport

    Creator:
    Genualdi, Susan A.
    Abstract:
    The use of semi-volatile organic compounds (SOCs) as molecular markers to identify the contributions of regional and long-range atmospheric transport, as well as current and historic sources, and contaminant deposition in remote ecosystems of the Western U.S. was investigated. Trans-Pacific air masses influenced by Siberian biomass burning events had elevated...
    Resource Type:
    Dissertation
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    ). LITERATURE CITED (1) Bailey, R.; Barrie, L. A.; Halsall, C. J.; Fellin, P.; Muir, D. C. G. Journal of

  • Use of Targeted and Non-Targeted Analysis to Study Complex PAH Environmental Mixtures

    Creator:
    Chibwe, Leah
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants formed from the incomplete combustion of organic material. These contaminants are of concern because of their widespread presence in the environment and toxic properties. In addition, PAHs encompass a class of diverse compounds with varying physicochemical properties and exist in the environment as...
    Resource Type:
    Dissertation
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    toxicity assays demonstrated increased toxicity postbioremediation in four soil extract fractions (C, D

  • Determination of fluorochemicals in waste-dominated aqueous systems

    Creator:
    Huset, Carin A.
    Abstract:
    While fluorochemicals have been detected all over the world and in wastewater treatment plants, the effect of wastewater effluent on the receiving waters has not been evaluated. In the first study, the mass flow of fluorochemicals emanating from wastewater treatment plants along the Glatt River in Switzerland was evaluated. The...
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    Dissertation
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    year opened for Site D……………………..….... 122 LIST OF APPENDIX FIGURES (Continued

  • Wide band gap semiconductors and insulators : synthesis, processing and characterization

    Creator:
    Hersh, Peter A.
    Abstract:
    The work presented here is focused on applying basic principles of solid-state chemistry to the study and development of new wide band-gap semiconductors and insulators for photovoltaic and electronic-device applications. Analysis of crystal structure, band structure, optical band gap, morphology and transport properties provides fundamental insight into materials performance as...
    Resource Type:
    Dissertation
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    ), D. Film on SrTiO3……………………………… 5.5 Rocking curves for the (005) peaks of BiCuSeO

  • Tracking semi-volatile organic pollutants in remote lake systems

    Creator:
    Usenko, Sascha
    Abstract:
    SOCs volatility and persistence properties cause many SOCs to become ubiquitous in the environment as well as accumulate in areas with lower temperatures such as polar or orographic regions. Many anthropogenic SOCs pose a serious risk to human and ecosystem health because of their persistent, bioaccumulative, and toxic properties in...
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    Dissertation
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    ………………………………………….. 149 APPENDIX C. Lake Water SOC Database ………………………………… 164 APPENDIX D. Sediment SOC Database

  • The identification and quantitation of complex polycyclic aromatic hydrocarbon mixtures in environmental samples using comprehensive two-dimensional gas chromatography with time-of-flight mass spectrometry

    Creator:
    Manzano, Carlos A.
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants and are mostly products of the incomplete combustion of organic material. PAHs are often found in environmental samples as a complex mixture of isomers. In addition, the same sources that produce complex PAH mixtures also produce other poorly characterized mixtures of organic compounds,...
    Resource Type:
    Dissertation
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     …..……………………………………. Appendix  C  …..……………………………………. Appendix  D  …..……………………………………. Appendix  E