Index Catalog // ScholarsArchive@OSU

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Creator:: Song, Zifeng
Abstract:: Mass Spectrometry has emerged as an analytical core technique in omics sciences, in particularly mass spectrometry has advanced the fields of proteomics, metabolomics and lipidomics in recent years. Mass spectrometric techniques have enabled the characterization and determination of abundance levels of a wide range of biomolecules at molecular and system-wide...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Claudia S. Maier Mass

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:: Yang, Liping
Abstract:: The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....
Resource Type:: Dissertation
Full Text:: : ______________________________________________________________ Dr. Claudia S. Maier

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Creator:: Huang, Lin
Abstract:: Oxidative stress is deﬁned as an imbalance that favors the production of reactive oxygen species (ROS) over an organism's antioxidant defense. ROS have the ability to damage, either directly or indirectly, biomolecules including DNA, proteins, carbohydrates, and lipids. Various pathological conditions and environmental and chronic diseases have been associated with...
Resource Type:: Dissertation
Full Text:: Abstract approved: ______________________________________________________ Claudia S. Maier

Alternating Between Amperometric Copper Detection and Potentiometric Calcium Detection on a Carbon-based Ion-selective Electrode

Creator:: Park, Suji
Abstract:: The unique capability of carbon-based ion-selective electrode (ISE) to perform highly sensitive anodic stripping voltammetry, while maintaining all the properties of an ISE, is demonstrated in terms of sensitivity, detection limit, response time and selectivity. Square wave anodic stripping voltammetry involves deposition and dissolution steps of metal ions, which means...
Resource Type:: Masters Thesis
Full Text:: : _____________________________________________________________________ Claudia S. Maier The unique capability of carbon-based ion-selective electrode (ISE) to

Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Creator:: Chavez, Juan D.
Abstract:: Oxidative stress is recognized as an important underlying factor in the pathogenesis of many degenerative diseases as well as normal senescence. The free radicals, reactive oxygen species (ROS) and electrophiles produced during oxidative stress are capable of modifying nucleic acids, lipids and proteins. There are a variety of oxidative modifications...
Resource Type:: Dissertation
Full Text:: :___________________________ Claudia S. Maier Oxidative stress is recognized as an important underlying factor in the

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Creator:: Tzeng, Shin-Cheng
Abstract:: Alcoholic liver disease (ALD) continues to be one of the major public health problems in the United States and worldwide. Complicated by factors including gender, polymorphisms of alcohol-metabolizing enzymes, immunologic factors, exposures to other substances/drugs, hepatic viral infections, nutritional deficiencies, and obesity, ALD is a complex disease that requires a...
Resource Type:: Dissertation
Full Text:: Model Abstract approved: Dr. Claudia S. Maier Alcoholic liver disease (ALD

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Creator:: Wu, Jianyong
Abstract:: The adduction of proteins and other biomolecules by electrophilic lipid peroxidation products such as 4-hydroxy-2-nonenal (HNE), 4-oxo-2-nonenal (ONE), malondialdehyde (MDA) or acrolein (ACR) is thought to be an initiating and/or propagating factor in the pathophysiology of several diseases such as atherosclerosis, diabetes, Alzheimer's, Parkinson's and other age-related disorders. The identification...
Resource Type:: Dissertation
Full Text:: major professor, Dr. Claudia S. Maier for providing guidance, support, encouragement, and trust. In

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Creator:: Zandkarimi, Fereshteh
Abstract:: State-of-the-art, high-resolution mass spectrometry techniques for acquisition of metabolomic and lipidomic data coupled with advanced computational methods provide new opportunities for interpreting large and complex datasets and comprehending the underlying biological processes of diseases. Both metabolomics and lipidomics strive to obtain comprehensive analyses of small molecules, i.e., metabolites and lipids,...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Claudia S. Maier State-of-the-art, high-resolution mass spectrometry techniques for

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Creator:: Nirudodhi, Sasidhar N.
Abstract:: Proteins are essential to all biological systems. Proteins participate in numerous cellular processes by interacting with other proteins, other metabolites and membranes in a dynamic environment. Studying the structural and conformational properties of proteins in the solution phase is necessary to understand their protein folding and interaction dynamics. This research...
Resource Type:: Dissertation
Full Text:: Conformational Dynamics in Large Protein Complexes Abstract approved: Claudia S. Maier Proteins are essential

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

Creator:: Wang, Jing
Abstract:: Dysfunction of mitochondria has been linked to aging and the pathogenesis of many degenerative diseases. Aside from their primary function in energy production, mitochondria are considered as a major source and target of reactive oxygen and nitrogen species (ROS/RNS) in cells as well. The mitochondrial thiol proteome is a subset...
Resource Type:: Dissertation
Full Text:: : Claudia S. Maier Dysfunction of mitochondria has been linked to aging and the pathogenesis of many

ScholarsArchive@OSU

Advanced Mass Spectrometry Techniques for Characterizations of Proteome and Lipidome Profiles of Osteosarcoma Cells

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Mass-Spectrometric Methods for OxPTM Characterization and Quantitative Proteomics of Oxidative Stress Response

Alternating Between Amperometric Copper Detection and Potentiometric Calcium Detection on a Carbon-based Ion-selective Electrode

Mass spectrometry-based identification and characterization of protein and peptide adducts of lipoxidation-derived aldehydes

Label-free mass spectrometry-driven methods for elucidating adaptive responses of the hepatic mitochondrial proteome in an alcoholic fatty liver disease model

Tandem mass spectrometric analysis of protein and peptide adducts of lipid peroxidation-derived aldehydes

Development and Application of Mass Spectrometry-driven Methods for the Detection and Characterization of Biomolecular Signatures of Diseases

Hydrogen/deuterium exchange mass spectrometry as a technology platform for studying conformational dynamics in large protein complexes

Chemical labeling methods and mass spectrometry of mitochondrial thiol proteomes

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