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Filtering by: Creator Palo, D. Remove constraint Creator: Palo, D. Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry License All rights reserved Remove constraint License: All rights reserved

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  • Studies toward the total synthesis of phorboxazole A

    Creator:
    Kuntiyong, Punlop
    Abstract:
    Studies toward the total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, were conducted and resulted in a route to an advanced intermediate, C4-C32, for this purpose. A key feature of our approach is the stereoselective synthesis of two cis-2,6-disubstituted tetrahydropyrans present in the macrolide portion of...
    Resource Type:
    Dissertation
    Full Text:
    TOTAL SYNTHESIS OF PHORBOXAZOLE A. Abstract approved: James D. White Studies toward the total

  • Synthesis of furanoeremophilane sesquiterpenoids

    Creator:
    Shanmugham, Meenakshi Sundaram
    Abstract:
    Two approaches to the tricyclic core of the furanoeremophilane sesquiterpenoids are described. The first approach entails a projected Diels-Alder/retro Diels-Alder reaction of an acetylenic oxazole 64. Construction of the pivotal aldehyde 67 commenced from ketone 68. The acetyenic moiety was then introduced via a Felkin-Ahn addition of lithiopropyne to aldehyde...
    Resource Type:
    Dissertation
    Full Text:
    FURANOEREMOPHILANE SESQUITERPENOIDS Abstract approved: James D. White Two approaches to the tricyclic core of the

  • Total synthesis of phorboxazole A

    Creator:
    Lee, Tae Hee
    Abstract:
    The total synthesis of a highly potent cytotoxic marine natural product, phorboxazole A, is described. Both a palladium(II)-mediated and a palladium(II)-catalyzed intramolecular alkoxycarbonylation were used as key steps for the preparation of the two cis-2,6-disubstituted tetrahydropyran rings (C22-C26 and C11-C15) of phorboxazole A. The synthesis used a convergent approach involving...
    Resource Type:
    Dissertation
    Full Text:
    : James D. White The total synthesis of a highly potent cytotoxic marine natural product

  • Total synthesis of indole alkaloids: pt. 1. Asymmetric synthesis of (-)-ibogamine. pt. 2. An approach toward the synthesis of koumine

    Creator:
    Choi, Younggi
    Abstract:
    PART I. The preparation of (-)-ibogamine (1) in fourteen steps from benzoquinone and in 10% overall yield is a powerful illustration of the value of the asymmetric Diels-Alder reaction as a starting point in a multistep synthesis. All four cycloadducts, 70, 77, 84 and 96, obtained with the (S)-BINOL-TiCl₂ complex...
    Resource Type:
    Dissertation
    Full Text:
    SYNTHESIS OF KOUMINE. Abstracted approved: James D. White PART I. The preparation of ()-ibogamine (1) in

  • Semi-volatile organic compounds as molecular markers for atmospheric and ecosystem transport

    Creator:
    Genualdi, Susan A.
    Abstract:
    The use of semi-volatile organic compounds (SOCs) as molecular markers to identify the contributions of regional and long-range atmospheric transport, as well as current and historic sources, and contaminant deposition in remote ecosystems of the Western U.S. was investigated. Trans-Pacific air masses influenced by Siberian biomass burning events had elevated...
    Resource Type:
    Dissertation
    Full Text:
    ). LITERATURE CITED (1) Bailey, R.; Barrie, L. A.; Halsall, C. J.; Fellin, P.; Muir, D. C. G. Journal of

  • Fluorinated and deuterated surrogates for quantifying microbial transformation of chlorinated ethenes and ethanes in anaerobic groundwater

    Creator:
    Ennis, Elliot G.
    Abstract:
    Chlorinated aliphatic hydrocarbons (CAHs) such as vinyl chloride (VC) and 1,-2 dichioroethane (DCA), are wide-spread groundwater pollutants found at many contaminated field sites around the world. Quantitative tools are needed to determine the in situ rates of VC and DCA transformation to ethene in contaminated groundwater. The objective of this...
    Resource Type:
    Masters Thesis
    Full Text:
    Dichloroethane 1,2 Dichlorethane-d 4 /~ >=<-----► H Cl D~D--------► )=<° I\ D D D Cl Ethene-d4 VC

  • Use of Targeted and Non-Targeted Analysis to Study Complex PAH Environmental Mixtures

    Creator:
    Chibwe, Leah
    Abstract:
    Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous contaminants formed from the incomplete combustion of organic material. These contaminants are of concern because of their widespread presence in the environment and toxic properties. In addition, PAHs encompass a class of diverse compounds with varying physicochemical properties and exist in the environment as...
    Resource Type:
    Dissertation
    Full Text:
    toxicity assays demonstrated increased toxicity postbioremediation in four soil extract fractions (C, D

  • Investigating Low-Frequency Vibrations in Condensed Matter Using Time-Resolved Third-Harmonic Generation Spectroscopy

    Creator:
    Wang, Liang
    Abstract:
    In this thesis, I present a new method we developed to study low frequency (< 700 cm⁻¹) vibrational dynamics: Time-resolved third-harmonic generation (TRTHG) spectroscopy. Among a variety of vibrational spectroscopy techniques, TRTHG differentiates itself with robustness, versatility, and simplicity. In TRTHG experiment, that involves only two ultrashort laser pulses, the...
    Resource Type:
    Masters Thesis
    Full Text:
    of Physical Chemistry, Annual Reviews: Palo Alto, 2007; Vol. 58, pp 461-488. 4. McCamant, D. W

  • Determination of fluorochemicals in waste-dominated aqueous systems

    Creator:
    Huset, Carin A.
    Abstract:
    While fluorochemicals have been detected all over the world and in wastewater treatment plants, the effect of wastewater effluent on the receiving waters has not been evaluated. In the first study, the mass flow of fluorochemicals emanating from wastewater treatment plants along the Glatt River in Switzerland was evaluated. The...
    Resource Type:
    Dissertation
    Full Text:
    year opened for Site D……………………..….... 122 LIST OF APPENDIX FIGURES (Continued

  • Employing capillary electrophoresis as a separation method for pharmaceutical analysis

    Creator:
    Lessard, Laura L.
    Abstract:
    Capillary electrophoresis as a technique has many applications in a broad range of fields including forensics, environmental analysis, and biological analysis and as a separation method for samples such as oligonucleotides, peptides, proteins, and pharmaceuticals. The research conducted herein is for the antibiotic pharmaceutical ciprofloxacin HCl and three impurities. Sample...
    Resource Type:
    Masters Thesis
    Full Text:
    -cyclopropy!-4-oxo-6-(piperazin-! -y!)-I,4 -dihydroquino!ine-3-carboxylic acid (Impurity D) I-cycIopropyI