Index Catalog // ScholarsArchive@OSU

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Creator:: Tonsiengsom, Sorasaree
Abstract:: Studies toward the total syntheses of highly potent cytotoxic alkaloids including the bromopyrrole alkaloids and indole alkaloids were conducted and are described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
Resource Type:: Dissertation
Full Text:: : STUDIES TOWARD THE TOTAL SYNTHESIS OF ALKALOIDS: NAGELAMIDE A AND D, AGELASTATIN D, DRAGMACIDIN A-C

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Creator:: Li, Xin
Abstract:: This dissertation is separated into two parts according to the two major distinct research projects. In Part I, the full account of synthetic studies toward C10-functionalized lycopodium alkaloids is described. In Part II, the detailed discussion on the exploration of the Pummerer cyclization methodology and its application to the total...
Resource Type:: Dissertation
Full Text:: of multiple abietane diterpenoids (ent-triptobenzene T, vitexifolin C, hinokiol, 4-epi

Development and application of an analytical technique for the determination of methylmercury compounds in environmental samples based on isolation by distillation, followed by purge-and-trap sample concentration and GC/MS separation and detection, after aqueous phase ethylation with sodium tetraethylborate

Creator:: Rice, William R.
Abstract:: An analytical technique has been developed for the determination of methylmercury compounds in environmental samples. The technique is based on a two-stage procedure. In the first stage, methylmercury compounds are isolated from the sample matrix as methylmercury chloride (MeRgCl) by distillation. The distillation procedure is based on a series of...
Resource Type:: Masters Thesis
Full Text:: Detectiol1 after Aqueous Phase Ethylation with Sodium Tetraethylborate. Abstract approved: - / John C

Strategic Application of Computations to Diverse Chemical Systems

Creator:: Brueckner, Alexander C.
Abstract:: My work has focused on streamlining the study of organic compound structure, properties, and reactions by 1) understanding and using available computational software, 2) developing software packages to facilitate data manipulation as well as augment public programs, and 3) applying public and in-house developed software to further the understanding of...
Resource Type:: Dissertation
Full Text:: effect and to explore the non-classical C-H/D hydrogen bonding. However, the fragments were unable to

Carbon Nanodots as Biolabels for Fluorescence Immunoassays

Creator:: Wu, Yuanyuan
Abstract:: There has been a tremendous growth in interest in carbon nanodots (C-dots) in the past several years. As a nascent nanomaterial, C-dots have shown great promise in applications that benefit from their superior water dispersibility, low toxicity, non-blinking fluorescent output, chemical and biological compatibility, ease of functionalization and resistance to...
Resource Type:: Dissertation
Full Text:: : ______________________________________________________ Vincent T. Remcho There has been a tremendous growth in interest in carbon nanodots (C

Surface composition and orientation of room temperature ionic liquids

Creator:: Law, George
Abstract:: In this thesis, we investigated the surface composition and orientation of both pure room-temperature ionic liquids (Ils) and binary mixtures of the ILs of the type consisting of the 1-alkyl-3-methylimidazolium ([C[subscropt n]mim]⁺, n=4, 8, and 12) cation coupled with either [PF₆]⁻, [BF₄]⁻, [Cl]⁻, or [Br]⁻. The surfaces of the ILs...
Resource Type:: Dissertation
Full Text:: ........................................................... 60 4.6 Experimental H/C ratios from 2.0-keV Ne ........................... 61 +4.7 Expenmental F/C

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Creator:: Vellucci, Jessica K.
Abstract:: Aminal radical intermediates were generated by the method of radical translocation and reacted in C-C bond forming reactions with electronically deficient alkenes (Schiedler et al. Org. Lett. 2012, 14, 6092). Aminal radical intermediates can participate in inter- and intra-molecular reactions using both Bu3SnH and (TMS)₃SiH as hydride donors. Carbon–carbon bonds...
Resource Type:: Dissertation
Full Text:: Robinson, C. H.; Gonj, O.; Mitchell, A.; Oliveto, E. P.; Barton, D. H. R. Tetrahedron 1965, 21, 743. 18

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Creator:: Barsamian, Adam L.
Abstract:: Two distinct strategies were explored for the enantioselective synthesis of α-heteroatom substituted alkyl boronic esters by stereoselective reagent-controlled homologation using transient chiral carbenoid reagents CHYMX (Y = heteroatom, X = nucleofuge, M = electrofuge). In the first case, a stereospecific reagent-controlled homologation (sStReCH) approach to α-alkoxyalkylboronates using α-metalated S,O- and...
Resource Type:: Dissertation
Full Text:: -benzodithiolane. Treatment of trans or cis-102 with EtMgCl (in THF at –78 °C) gave configurationally stable

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Creator:: Ferreira, Andrew
Abstract:: The first part of this manuscript is about the total synthesis of the Arundo donax bis(indole) natural products. The A. donax alkaloids were prepared using the first example of an ynindole Diels–Alder reaction. Each were then separated, isolated, and determined to have stable enantiomeric conformations at room temperature (Chen, J.;...
Resource Type:: Dissertation
Full Text:: enantiomeric conformations at room temperature (Chen, J.; Ferreira, A. J.; Beaudry, C. M. Angew. Chem. Int

Computational Rationalizations of Mechanism and Stereocontrol in Small-Molecule Lewis Base Organocatalysis

Creator:: McCauley-Walden, Daniel W.
Abstract:: My work has focused on investigating synthetic organic reactions using applied computational methods. Non-covalent interactions are critical to catalysis, mechanism, and stereoselectivity, with the most prominent interaction for isothioureas being the S···O contact between the catalyst sulfur atom and the oxygen of the acyl group. A comprehensive joint experimental and...
Resource Type:: Dissertation
Full Text:: , a C–H···O between the substrate and the catalyst oxygen atom favors lactonization. Computed TSs

ScholarsArchive@OSU

Studies toward the total synthesis of alkaloids : nagelamide A and D, agelastatin D, dragmacidin A-C, salacin and almazoles

Part I: Synthetic Studies toward C10-functionalized Lycopodium Alkaloids. Part II: Exploration of the Pummerer Cyclization and Its Application to the Total Syntheses of the Abietane Diterpenoids

Strategic Application of Computations to Diverse Chemical Systems

Carbon Nanodots as Biolabels for Fluorescence Immunoassays

Surface composition and orientation of room temperature ionic liquids

Total Synthesis of Goniomitine : Development of Aminal and α-Amino Radicals in the Synthesis of Nitrogen-Rich Natural Products

Investigation of Chain Extension Approaches for the Stereoselective Reagent-Controlled Synthesis of alpha-Heteroatom Substituted Alkyl Boronic Esters

Total Synthesis of Tryptamine Alkaloids from the Arundo and Leuconotis Genera

Computational Rationalizations of Mechanism and Stereocontrol in Small-Molecule Lewis Base Organocatalysis

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