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Filtering by: Creator Jung, Bong Nam Academic Affiliation Chemistry Subject Ligand binding (Biochemistry)

Active site studies and design of ligands for affinity column separation of 2,5-dihydroxyacetanilide epoxidase (DHAE) I and II

Creator:

Allen, Scott E.

Abstract:

A series of compounds, 7-8 and 20-25, were tested as competitive inhibitors of 2,5-dihydroxyacetanilide epoxidase I (DHAE I) and DHAE II. A Hammett plot was constructed for each enzyme to determine the effect of electron density on inhibition. DHAE I gave a linear, highly correlated plot (r²=0.91) that signifies the...

Resource Type:

Dissertation