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Filtering by: Creator Reeher, Max M. (Max Moore), b. 1892 Academic Affiliation Chemistry Subject Nuclear receptors (Biochemistry)

Effects of small molecule ligands on the conformational dynamics of the Farnesoid X Receptor ligand binding domain (FXR-LBD)

Creator:

Yang, Liping

Abstract:

The Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily of transcription factors that plays a key role in the regulation of bile acids, lipid and glucose metabolisms. The regulative function of FXR is governed by conformational changes of the ligand binding domain (LBD) upon ligand binding....

Resource Type:

Dissertation

Full Text:

Figure S3.1 A SDS PAGE of purified hFXR-LBD; B, MS spectrum of purified hFXR-LBD