Studies toward the total syntheses of highly potent cytotoxic alkaloids
including the bromopyrrole alkaloids and indole alkaloids were conducted and are
described. Studies carried out in the course of this dissertation consist of five total syntheses of natural products that include bromopyrrole alkaloids nagelamide A, D and agelastatin D as...
The objective of this research was to assess the variability of POP deposition by snow on a 10 km spatial scale by measuring the POP concentrations in fresh-fallen snow from remote alpine sites. Samples of pre-metamorphic snow were concurrently collected from three remote alpine sites, of matched altitude and exposure,...
Two related techniques, based upon ion-exchange solid phase extraction, have been
developed for the determination of arsenic speciation. The inorganic arsenic species
arsenite (As(III)) and arsenate (As(V)) are separated by anion-exchange and detected with
graphite furnace atomic absorption spectrophotometry (GFAAS) with a nickel matrix
modifier. The first separation technique, which...
A comparative study was made on the effect of urea denaturation
of bovine serum albumin (BSA), polyglycyl BSA and poly-L-phenylalanyl
BSA. The denaturation process was followed by ultraviolet
spectrophotometry and optical rotation.
A blue shift in the absorption maximum at 278 mμ was observed
in urea denatured proteins, In 7M...
The ethyl acetate extract of the culture filtrate of the marine Ascomycete,
Leptosphaeria oraemaris (Linder) yielded a novel metabolite
designated by the common name leptosphaerin. An x-ray crystallographic
structure analysis was disproved by the synthesis of 3-acetoxy-S-(1,2-dihydroxyethyl)-
3-pyrrolin-2-one 1, starting with N,N-dibenzylhydroxylamine
47 and D-mannitol 44. Oxidation of 47 followed...