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Filtering by: Creator McGrath, Daniel Remove constraint Creator: McGrath, Daniel Academic Affiliation Chemistry Remove constraint Academic Affiliation: Chemistry

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  • Employing capillary electrophoresis as a separation method for pharmaceutical analysis

    Creator:
    Lessard, Laura L.
    Abstract:
    Capillary electrophoresis as a technique has many applications in a broad range of fields including forensics, environmental analysis, and biological analysis and as a separation method for samples such as oligonucleotides, peptides, proteins, and pharmaceuticals. The research conducted herein is for the antibiotic pharmaceutical ciprofloxacin HCl and three impurities. Sample...
    Resource Type:
    Masters Thesis
    Full Text:
    is dedicated to Keitha, David, Benjamin, Peggy and Daniel. I couldn't have done this without you

  • New Treatments for HIV and Cancer: Uncovering Bioactive Compounds from Small Molecule Sources

    Creator:
    Overacker, Ross D.
    Abstract:
    Small molecule drugs have been instrumental in our fight against diseases, beginning when some of the earliest ancient cultures used plant remedies to treat illnesses. More recently, the skill of isolating and characterizing the active ingredients within bioactive plants and microbial extracts has led to the isolation and design of...
    Resource Type:
    Dissertation
    Full Text:
    ABSTRACT OF THE DISSERTATION OF Ross Daniel Overacker for the degree of Doctor of Philosophy in Chemistry

  • Gene Activation Strategies in Filamentous Fungi for Natural Products Discovery

    Creator:
    Adpressa, Donovon A.
    Abstract:
    Fungi have long been a prolific source of clinically approved drugs. The antibiotic penicillin, the cholesterol lowering statins, and the immunosuppressant cyclosporine have changed the treatment of human diseases in the last century. Recently, genome analysis of filamentous fungi has revealed that the biosynthetic potential for natural product expression is...
    Resource Type:
    Dissertation
    Full Text:
    perspective on the future of fungal natural products discovery. 11 1.6 References 1. Daniel A

  • Studies towards the total syntheses of (+)-phomactins A, D and G

    Creator:
    Schwartz, Keith D.
    Abstract:
    Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
    Resource Type:
    Dissertation
    Full Text:
    Kirkpatrick David & Krisanna Sanders Dr. David Ihle Emile J. Firpo Dr. Daniel J. T. Myles Rajan Juniku

  • Capturing Molecular Movies of Organic and Organometallic Systems in Solution by Ultrafast Spectroscopy

    Creator:
    Boulanger, Sean A.
    Abstract:
    Ultrafast spectroscopy can exploit the structure-function relationship of chemical- and biological-based systems. More specifically, femtosecond stimulated Raman spectroscopy (FSRS) provides ground- and excited-state vibrational information with simultaneously high spectral (spatial) and temporal resolutions. The electronic counterpart, femtosecond transient absorption (fs-TA), complements FSRS data analysis as part of a comprehensive approach...
    Resource Type:
    Dissertation