Index Catalog // ScholarsArchive@OSU

The preparation of d-arginine hydrochloride from salmon testes

Creator:: Ruggles, Judson Gilbert
Resource Type:: Masters Thesis
Full Text:: The preparation of d-arginine hydrochloride from salmon

Synthesis of 2-substituted-5, 8-dihydroxypyrimido (4,5-d) pyridazines

Creator:: McMahill, Paul Edward
Resource Type:: Masters Thesis
Full Text:: Synthesis of 2-Substituted-5,8-Dihydropyrimido (4,5-d

Catalytic desymmetrization of D₂d̳-symmertic proprochiral tetrasubstituted biphenyl compounds: a novel approach to the synthesis of axially chiral C₂-symmetric molecules

Creator:: Gunderson, Jeremey Tyson
Abstract:: Many D2d-symmetric 2,2',6,6'-tetrasubstituted biphenyls are readily prepared via net oxidative dimerization of appropriate 1,3-disubstituted benzenes. Conversion of such proprochiral compounds to useful C2-symmetric chiral biphenyls requires formal replacement of two substituents on opposing aryl ring units with alternate groups. This under exploited desymmetrization tactic has been demonstrated for the generation...
Resource Type:: Masters Thesis
Full Text:: esters (31a-d) aimed at the acquisition of data regarding enzyme activity and enzymatic affinity for

Studies towards the total syntheses of (+)-phomactins A, D and G

Creator:: Schwartz, Keith D.
Abstract:: Studies towards the total synthesis of (+)-Phomactin A (1), D (6), and G (9), fungal metabolites with unique molecular architecture and pronounced biological activity, are described. These studies resulted in the synthesis of advanced intermediates 354 and 356, which contain all of the carbon atoms of 1, 6 and 9....
Resource Type:: Dissertation
Full Text:: DISSERTATION OF Keith D. Schwartz for the degree of Doctor of Philosophy in Chemistry presented

Enantioselective Total Syntheses of Quinolizidine Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A

Creator:: Veerasamy, Nagarathanam
Abstract:: The enantioselective total synthesis of quinolizidine-containing natural product cermizine D and formal syntheses of senepodine G and cermizine C has been achieved. These natural products are members of the lycopodium alkaloids, which have attracted significant attention due to their exciting biological activities and the diverse structural scaffolds. Key steps in...
Resource Type:: Dissertation
Full Text:: Lycopodium Alkaloid Cermizine D and Cytotoxic Marine Macrolide Mandelalide A. Abstract approved

The preparation of 2,4,7-trichloroimidazo [4,5-d] pyridazine and certain of its derivatives

Creator:: Laursen, Paul Herbert
Resource Type:: Dissertation
Full Text:: The preparation of 2,4,7-trichloroimidazo [4,5-d

Synthesis of substituted cyclooctatetraenide dianions ; Cycloheptadienyl complexes of the ḏ- and f̲-transistion elements ; Reactions of cyclohexanone with metal vapors

Creator:: Miller, Jeffrey Templeton
Abstract:: I. Lithium alkyl and aryl monosubstituted cyclooctatetraenide dianions (Li₂ C₈H₇-R; R = methyl, n- butyl, sec- butyl, tert- butyl, phenyl and benzyl) were synthesized by the reaction of the appropriate organolithium reagent with cyclooctatetraene in diethyl ether or tetrahydrofuran. The reaction occurred cleanly and with good yield of lithium monosubstituted...
Resource Type:: Dissertation
Full Text:: OF SUBSTITUTED CYCLOOCTATETR.AENIDE DIANIONS. LI. CYCLOHEPTADIENYL COMPLEXES OF THE d- AND f

A stereochemically controlled approach to the morphine alkaloids: racemization of 8,9-benzo-4,5-dihydro-6,7-pyrido[4,3-d] oxanin-3(2H)-ones

Creator:: Runyan, Mark T.
Abstract:: A method for the control of absolute stereochemistry in morphine syntheses has been demonstrated by the resolution and efficient racemization of the advanced morphine precursor , 9-methoxy-3-methyl-5,6-dihydro-3H-benzofuro[3,2-e]isoquinoline- 7(7aH)-one, I. This was accomplished by the facile coversion of optically resolved I to its ring opened form, 5,6,7,8-tetrahydro-10-methoxy-3-methyl-7-oxo[1]benzoxonino[ 6,7-c]pyridinium tosylate, II, (Equation...
Resource Type:: Masters Thesis
Full Text:: alkaloids: racemization of 8,9-benzo-4,5-dihydro-6,7-pyrido[4,3-d] oxanin-3(2H)-ones AN ABSTRACT OF THE

Examination of low-lying rovibrational states of D₃[subscript h] oblate top molecules using high resolution FTIR and coherent anti-Stokes Raman spectroscopies

Creator:: Kirkpatrick, Robynne
Abstract:: Interesting rovibrational characteristics of two D_(3h) oblate symmetric top molecules were studied. Hamiltonian models for the fine rovibrational level structure of [1.1.1]propellane (propellane) were obtained for many low-lying modes. Ground state parameters (GSP) that are not exclusively K^(2n) dependent were obtained. Initially, the GSP were used in conjunction with density...
Resource Type:: Dissertation
Full Text:: particular mode number. The irreducible dimension of the mode is denoted d, where, for a two dimensional

Synthetic studies on marine natural products : Part 1. Synthesis of the sesquiterpenoid dihydropallescensin D via manganese(III)- mediated carbocyclization. Part 2. Approaches toward the synthesis of prianosin and discorhabdin alkaloids

Creator:: Yager, Kraig M.
Resource Type:: Dissertation
Full Text:: . Synthesis of the sesquiterpenoid dihydropallescensin D via manganese(III)- mediated carbocyclization. Part 2

Atmospheric trace element abundances associated with slash burning

Creator:: Ungerer, Carl Andre
Abstract:: The atmospheric trace element abundances associated with slash burning have been measured by instrumental neutron activation analysis (INAA). On site ground level samples were collected during the slash burning season using high volume samplers and a cascade impactor. In addition to the air samples, soil, wood and ashed wood samples...
Resource Type:: Masters Thesis
Full Text:: corrections to a minimum, clean sample handling methodology was used at all times. Prior to mounting the

The determination of gasoline and alkyl benzenes in aqueous solution and the development of a remote reaction chamber for fiber optic remote sensing

Creator:: Waddle, Robert D.
Abstract:: The development and optimization of a single-phase derivatization technique for small ring aromatics in water are presented. Also described are the design, optimization and application of a remote reaction chamber for fiber optic sensing. Aqueous solutions of the major aromatic compounds in gasoline are derivatized to o-nitrosophenol-Cu complexes with a...
Resource Type:: Masters Thesis
Full Text:: Privacy J. D. Ingle, Jr. The development and optimization of a single-phase derivatization technique for

Total synthesis of (-)-7-epicylindrospermopsin

Creator:: Hansen, Joshua D.
Abstract:: The first asymmetric synthesis of (-)-7-epicylindrospermopsin via intramolecular nitrone cycloaddition is described. The synthesis utilized a convergent approach to prepare the cycloaddition precursor 176, which was assembled by condensation of hydroxylamine 175 with aldehyde 145. Hydroxylamine 175 was synthesized from ethylene glycol (166) in seven steps. Aldehyde 145 was completed...
Resource Type:: Dissertation
Full Text:: OF THE DISSERTATION OF Joshua D. Hansen for the degree of Doctor of Philosophy in Chemistry

Synthetic transformations of shikimic acid

Creator:: White, Edward D., III
Abstract:: Four strategies which involve synthetic elaboration of the shikimate nucleus are discussed. Methyl shikimate was differentially protected as the 3,4-0-cyclopentylidene ketal and as the 5- 0- tert- butyldiphenylsilyl ether. The methyl ester was then reduced with diisobutylaluminum hydride and the resulting allylic alcohol was oxidized to aldehyde 47 with pyridinium...
Resource Type:: Masters Thesis
Full Text:: OF THE THESIS OF Edward D. White III for the degree of Master of Science in Chemistry presented on

Approaches toward synthesis of the mycosporins

Creator:: Cammack, Janice H.
Abstract:: The mycosporins, formerly called P310's are secondary metabolites of fungi closely associated with fungal reproductive processes that require light. The structurally related iminomycosporins are found in marine plants and animals and may also have functions related to light. In this study, approaches toward the asymmetric synthesis of the mycosporins are...
Resource Type:: Dissertation
Full Text:: . James D. White Abstract approved: The mycosporins, formerly called P310's are secondary metabolites

Characterization and applications of polyphenol chemiluminescence reactions and flow cell instrumentation

Creator:: Miller, Robert J. (Robert James), 1933-
Resource Type:: Dissertation
Full Text:: approved: Redacted for Privacy James D. Ingle, Jr. This thesis encompasses the development of direct

Solid-phase synthesis and biophysical testing of uncharged acyclic oligonucleotide analogues

Creator:: Nelson, Jeffrey Stephen, 1962-
Resource Type:: Dissertation
Full Text:: -diethylaniline were added to the sample prior to loading on the column. 1H NMR (300 MHz, DMSO-d6): 8 7.39 (2H, d

Application of flow injection analysis to enzymatic fluorescence kinetic methods

Creator:: Elliott, Colin Bruce
Abstract:: Studies of the use of NADH as the monitored fluorophore for enzymatic fluorescence kinetic methods are discussed. Interference studies for the detection of NADH and the adaptation and optimization of fluorescence kinetic measurements to four serum assays are also described. A microcomputer-controlled flow injection analysis (FIA) system was designed and...
Resource Type:: Dissertation
Full Text:: Enzymatic Fluorescence Kinetic Methods Redacted for Privacy Abstract approved: -- James D. Ingle Jr

Development of stable x-ray fluorescent tracers for use in small water systems

Creator:: Dzata, Francis K. A.
Resource Type:: Masters Thesis
Full Text:: Tracers for use in Small Water Systems Abstract approved: Redacted for privacy Dr. Walter D. Loveland

Synthesis of epothilones and epothilone analogues

Creator:: Sundermann, Kurt F.
Abstract:: A convergent synthesis of epothilone B that generates all seven of its asymmetric centers in a completely stereoselective fashion has been completed. Key reactions include an anti-Felkin aldol condensation to set the C6 and C7 stereochemistry, a directed α-hydroxylation to install the C15 (S)-hydroxyl substituent, and a Wittig condensation to...
Resource Type:: Dissertation
Full Text:: epothilone B, epothilone D, and paclitaxel showed that the synthetic analogues were less potent than their

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